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• 产品描述： Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor, with an IC50 and a Kd of 145 nM and 12 nM for Mps1 and a Kd of 61 nM for Plk1.

• 靶点： Mps1:12 nM (Kd);GAK:140 nM (Kd);PLK1:61 nM (Kd);PLK3:1600 nM (Kd);PLK4:'3100 nM (Kd);STK33:5000 nM (Kd);Kinesin; PLK

• 体外研究：
  Mps1-IN-2 is a potent, selective and ATP-competitive Mps1 kinase inhibitor, with an IC50 and a Kd of 145 nM and 12 nM. Mps1-IN-2 also shows high affinity for PLK1 and GAK with Kds of 61 and 140 nM, respectively, but shows little or no inhibition on other 352 member kinases. Mps1-IN-2 can induces bypass of a checkpoint-mediated mitotic arrest in U2OS cells

• 参考文献：
  1. Kwiatkowski N, et al. Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat Chem Biol. 2010 May;6(5):359-68.

• 溶解性： soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.081 ml	10.404 ml	20.807 ml
  5 mM	0.416 ml	2.081 ml	4.161 ml
  10 mM	0.208 ml	1.04 ml	2.081 ml
  50 mM	0.042 ml	0.208 ml	0.416 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *