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• 产品描述： HA130 is a selective autotaxin (ATX) inhibitor with an IC50 of 28 nM.

• 靶点： Autotaxin:28 nM (IC50);PDE

• 体内研究：
  HA130 slows T cell migration across lymph node HEVs. HA130 decreases the outside HEVs/inside HEVs ratio by 3-4-fold compared to vehicle-treated animals vehicle. The s.c. administration of HA130 induces marked lymphocyte accumulation within the endothelial cell (EC) and sub-EC layers of HEVs in draining lymph nodes (LNs)

• 参考文献：
  1. Zhang Y, et al. Autotaxin through lysophosphatidic acid stimulates polarization, motility, and transendothelial migration of naive T cells. J Immunol. 2012 Oct 15;189(8):3914-3924. 2. Bai Z, et al. Constitutive lymphocyte transmigration across the basal lamina of high endothelial venules is regulated by theautotaxin/lysophosphatidic acid axis. J Immunol. 2013 Mar 1;190(5):2036-2048.

• 溶解性： DMSO  :  ≥  39  mg/mL  (84.18  mM)

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.158 ml	10.792 ml	21.585 ml
  5 mM	0.432 ml	2.158 ml	4.317 ml
  10 mM	0.216 ml	1.079 ml	2.158 ml
  50 mM	0.043 ml	0.216 ml	0.432 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

输入产品批号：

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *