| 产品描述： | ERK5-IN-1 is a potent ERK5 inhibitor with an IC50 of 87±7 nM. ERK5-IN-1 also inhibits LRRK2[G2019S] with an IC50 of 26 nM. |
| 靶点： |
ERK5:87 nM (IC50);LRRK2[G2019S]:26 nM (IC50);ERK |
| 体外研究： |
ERK5-IN-1 (Compound 5) exhibits a cellular EC50 for inhibiting epidermal growth factor (EGF) induced ERK5 autophosphorylation of 0.19±0.04 μM |
| 参考文献： |
1. Deng X, et al. Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones. Eur J Med Chem. 2013;70:758-767. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-20℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.176 ml |
10.88 ml |
21.761 ml |
| 5 mM |
0.435 ml |
2.176 ml |
4.352 ml |
| 10 mM |
0.218 ml |
1.088 ml |
2.176 ml |
| 50 mM |
0.044 ml |
0.218 ml |
0.435 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京