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• 产品描述： Lercanidipine is a calcium channel blocker of the dihydropyridine class.

• 靶点： Calcium Channel;CalciumChannel

• 体内研究：
  In chronically catheterised dogs with experimental renovascular hypertension, lercanidipine decreases diastolic blood pressure in a dose-dependent manner (ED25 = 0.9 mg/kg p.o). In the same animals, long term application of lercanidipine showed permanent decrease of diastolic blood pressure indicating no tolerance of the antihypertensive effect. Lercanidipine possesses significant anticonvulsant effect. It does not affect the muscle coordination or locomotor activity in mice[5]. In clinical studies, lercanidipine has a 24-hour antihypertensive effect and causes no significant increase in heart rate. Lercanidipine has been shown to be effective in a wide range of hypertensive patients, including mild-to-moderate hypertension, severe hypertension, the elderly, and those with isolated systolic hypertension. It is associated with a low rate of adverse events

• 细胞实验： Cells are incubated for 24 hours in DMEM+EFAF 0.2% and lercanidipine, then with lercanidipine and AcLDL for 24 hours. In the last 2 hours [14C]-oleic acid albumin complex is added for the determination of cholesterol esterification (ACAT activity). (Only for Reference)

• 参考文献：
  1.Shereen M. Tawakkol, et al. Analytical Chemistry Letters. 2014, 4:255-266. 2.Epstein M, et al. Heart Dis. 2001, 3(6):398-407. 3.Selvaraj N, et al. J Clin Diagn Res. 2015, 9(11):FF01-5. 4.Gasser R, et al. Journal of Clinical and Basic Cardiology. 1999, 2(2):169-174. 5.Canavesi M, et al. J Cardiovasc Pharmacol. 2004, 44(4):416-422.

• 溶解性： DMSO:64.8  mg/mL  (100  mM)    Ethanol:6.5  mg/mL  (10  mM)

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	1.522 ml	7.608 ml	15.216 ml
  5 mM	0.304 ml	1.522 ml	3.043 ml
  10 mM	0.152 ml	0.761 ml	1.522 ml
  50 mM	0.03 ml	0.152 ml	0.304 ml

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输入产品批号：

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *