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KN-92 (hydrochloride) 99%

KN-92 (hydrochloride)

源叶(MedMol)
S83292
1431698-47-3
C24H26Cl2N2O3S
493.4458
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S83292-1mg 99% ¥320.00元 >10 - - -
源叶(MedMol) S83292-5mg 99% ¥1070.00元 7 - - -
源叶(MedMol) S83292-10mg 99% ¥1820.00元 6 - - -
源叶(MedMol) S83292-25mg 99% ¥2970.00元 6 - - -
源叶(MedMol) S83292-50mg 99% ¥4560.00元 5 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

KN-92 hydrochloride is an inactive derivative of KN-93, without CaM kinase inhibitory activity. KN-92 hydrochloride is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93
产品描述: KN-92 hydrochloride is an inactive derivative of KN-93, without CaM kinase inhibitory activity. KN-92 hydrochloride is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93
靶点: CaMK
体外研究: KN-93 (5-50μM; 24 hours) inhibits LX-2 cell growth and KN-92 (5-50μM; 24 hours) is ineffective in blocking cell growth. The analysis of cell cycle regulator expression reveals that KN-93 rather than KN-92 reduced the expression of p53 and p21. Cell Viability Assay Cell Line: Human hepatic stellate cells (LX-2) Concentration: 5-50 μM Incubation Time: 24 hours Result: Ineffective in blocking cell growth.
参考文献: 1. Smyth JT, et al. Inhibition of the inositol trisphosphate receptor of mouse eggs and A7r5 cells by KN-93 via a mechanism unrelated to Ca2+/calmodulin-dependent protein kinase II antagonism. J Biol Chem. 2002;277(38):35061-35070. 2. An P, et al. KN-93, a specific inhibitor of CaMKII inhibits human hepatic stellate cell proliferation in vitro. World J Gastroenterol. 2007;13(9):1445-1448.
溶解性: Soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.027 ml 10.133 ml 20.266 ml
5 mM 0.405 ml 2.027 ml 4.053 ml
10 mM 0.203 ml 1.013 ml 2.027 ml
50 mM 0.041 ml 0.203 ml 0.405 ml
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参考文献

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