| 产品描述： | GNE-495 is a potent and selective MAP4K4 inhibitor with an IC50 of 3.7 nM. |
| 靶点： |
MAP4K4:3.7 nM (IC50);MAPK |
| 体外研究： |
GNE-495 is a potent and selective MAP4K4 inhibitor with efficacy in retinal angiogenesis. GNE-495 shows the best balance of MAP4K4 inhibition, permeability, microsomal stability, and cellular potency |
| 体内研究： |
GNE-495 is administered intraperitoneally to neonatal mouse pups at high doses: 25 and 50 mg/kg. GNE-495 shows good in vivo profile in all species tested, with low clearances, moderate terminal half-lives, and reasonable oral exposure levels (F=37-47%) |
| 参考文献： |
1. Ndubaku CO et al. Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis. ACS Med Chem Lett. 2015 Jun 29;6(8):913-8. |
| 溶解性： |
soluble in DMSO |
| 保存条件： |
-20℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.467 ml |
12.333 ml |
24.665 ml |
| 5 mM |
0.493 ml |
2.467 ml |
4.933 ml |
| 10 mM |
0.247 ml |
1.233 ml |
2.467 ml |
| 50 mM |
0.049 ml |
0.247 ml |
0.493 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京