Pimodivir

≥99%

Pimodivir

产品说明书产品使用指南

品牌：源叶(MedMol)

产品编号：S83758 一键复制产品信息

CAS号：1629869-44-8

分子式：C₂₀H₁₉F₂N₅O₂

分子量：399.394

别名：VX-787; VX 787; VX787; JNJ-63623872; JNJ63623872; JNJ 63623872;(2S,3S)-3-((5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)bicyclo[2.2.2]octane-2-carboxylic Acid JNJ-872; JNJ 8

货号	规格	价格	上海	北京	珠海	重庆	武汉
S83758-5mg促销	≥99%	￥740.00 ￥666.00 S83758-5mg ￥666.00 现货	5 5	-	-	-	-
S83758-10mg促销	≥99%	￥1230.00 ￥1100.00 S83758-10mg ￥1100.00 现货	3 3	-	-	-	-
S83758-25mg促销	≥99%	￥2380.00 ￥2140.00 S83758-25mg ￥2140.00 现货	2 2	-	-	-	-
S83758-50mg促销	≥99%	￥3500.00 ￥3150.00 S83758-50mg ￥3150.00 现货	2 2	-	-	-	-
S83758-100mg促销	≥99%	￥5100.00 ￥4590.00 S83758-100mg ￥4590.00 现货	1 1	-	-	-	-

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产品介绍参考文献质检证书(COA) 摩尔浓度计算器相关产品

产品描述：

Pimodivir, an influenza A virus polymerases inhibitor via oral, interacts with the viral PB2 subunit.

靶点：

Influenza Virus;InfluenzaVirus

体外研究：

Pimodivir is very potent against influenza A strains,and shows potent activity against all influenza A virus strains tested, with an EC50 range of 0.13 to 3.2 nM.

体内研究：

In mouse influenza model,Pimodivir (1, 3, or 10 mg/kg, bid) provided complete survival. Pimodivir (2, 6, and 20 mg/kg/day, p.o.) completely prevent death in the H1N1pdm virus infection in mice.

细胞实验：

Pimodivir is dissolved in DMSO.The compound cytotoxicity and efficacy testing is performed in 96-well plates with macrophages at 95% confluence. The compounds are added to the medium, and 30 min later, the cells are infected with virus or non-infected. The cell viability is analyzed with the Cell Titer Glo assay at 24 hpi. The luminescence is read with a PHERAstar FS plate reader.

动物实验：

The mice, infected intranasally with influenza virus, are given Pimodivir(prepared in 0.5% methylcellulose) twice a day.

参考文献：

1. Byrn RA, et al. PreClinicalal activity of VX-787, a first-in-class, orally bioavailable inhibitor of the influenza virus polymerase PB2 subunit. Antimicrob Agents Chemother. 2015 Mar;59(3):1569-82. 2. Smee DF, et al. Activities of JNJ63623872 and oseltamivir against influenza A H1N1pdm and H3N2 virus infections in mice. Antiviral Res. 2016 Dec;136:45-50. 3. Fu Y, et al. JNJ872 inhibits influenza A virus replication without altering cellular antiviral responses. Antiviral Res. 2016 Sep;133:23-31. 4. Boyd MJ, et al. Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors. Bioorg Med Chem Lett. 2015 May 1;25(9):11990-4.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.504 ml	12.519 ml	25.038 ml
5 mM	0.501 ml	2.504 ml	5.008 ml
10 mM	0.25 ml	1.252 ml	2.504 ml
50 mM	0.05 ml	0.25 ml	0.501 ml