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S83758

Pimodivir

源叶(MedMol) 99%
  • 英文名:
  • Pimodivir
  • 别名:
  • VX-787; VX 787; VX787; JNJ-63623872; JNJ63623872; JNJ 63623872;(2S,3S)-3-((5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)bicyclo[2.2.2]octane-2-carboxylic Acid JNJ-872; JNJ 8
  • CAS号:
  • 1629869-44-8
  • 分子式:
  • C20H19F2N5O2
  • 分子量:
  • 399.394
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源叶(MedMol) S83758-5mg 99% ¥1100.00元 预计交期:3-5天 - - - EA 加入购物车
源叶(MedMol) S83758-10mg 99% ¥1800.00元 预计交期:3-5天 - - - EA 加入购物车
源叶(MedMol) S83758-25mg 99% ¥3000.00元 预计交期:3-5天 - - - EA 加入购物车
源叶(MedMol) S83758-100mg 99% ¥7500.00元 预计交期:3-5天 - - - EA 加入购物车
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  • 提示:详情请下载说明书。
  • 产品描述: Pimodivir, an influenza A virus polymerases inhibitor via oral, interacts with the viral PB2 subunit.
  • 靶点: Influenza Virus;InfluenzaVirus
  • 体外研究:
    Pimodivir is very potent against influenza A strains,and shows potent activity against all influenza A virus strains tested, with an EC50 range of 0.13 to 3.2 nM.
  • 体内研究:
    In mouse influenza model,Pimodivir (1, 3, or 10 mg/kg, bid) provided complete survival. Pimodivir (2, 6, and 20 mg/kg/day, p.o.) completely prevent death in the H1N1pdm virus infection in mice.
  • 细胞实验: Pimodivir is dissolved in DMSO.The compound cytotoxicity and efficacy testing is performed in 96-well plates with macrophages at 95% confluence. The compounds are added to the medium, and 30 min later, the cells are infected with virus or non-infected. The cell viability is analyzed with the Cell Titer Glo assay at 24 hpi. The luminescence is read with a PHERAstar FS plate reader.
  • 动物实验: The mice, infected intranasally with influenza virus, are given Pimodivir(prepared in 0.5% methylcellulose) twice a day.
  • 参考文献:
    1. Byrn RA, et al. PreClinicalal activity of VX-787, a first-in-class, orally bioavailable inhibitor of the influenza virus polymerase PB2 subunit. Antimicrob Agents Chemother. 2015 Mar;59(3):1569-82. 2. Smee DF, et al. Activities of JNJ63623872 and oseltamivir against influenza A H1N1pdm and H3N2 virus infections in mice. Antiviral Res. 2016 Dec;136:45-50. 3. Fu Y, et al. JNJ872 inhibits influenza A virus replication without altering cellular antiviral responses. Antiviral Res. 2016 Sep;133:23-31. 4. Boyd MJ, et al. Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors. Bioorg Med Chem Lett. 2015 May 1;25(9):11990-4.
  • 溶解性: soluble  in  DMSO
  • 保存条件: -20℃
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 2.504 ml 12.519 ml 25.038 ml
    5 mM 0.501 ml 2.504 ml 5.008 ml
    10 mM 0.25 ml 1.252 ml 2.504 ml
    50 mM 0.05 ml 0.25 ml 0.501 ml
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