| 产品描述： | TAPI-1 is a TACE (ADAM17) inhibitor and blocks the shedding of several cell surface proteins. TAPI-1 is also a metalloproteinase (MMP) inhibitor |
| 靶点： |
TACE (ADAM17), MMP;MMP |
| 体外研究： |
TAPI-1 (1 µM for 30 min) increases cell viability in LPS-treated HK-2 cells. TAPI-1 attenuates oxidative stress and inflammatory cytokines LPS treatment significantly induces renal IL-6 and TNFα mRNA expression, while these changes is attenuated with TAPI-1 pretreatment in LPS-treated HK-2 cells. Cell Viability Assay Cell Line: LPS-treated HK-2 cells Concentration: 1 µM Incubation Time: 30 minutes (pre-treated) Result: Increased cell viability. |
| 参考文献： |
1. Bae EH, et al. Tumor necrosis factor α-converting enzyme inhibitor attenuates lipopolysaccharide-induced reactive oxygen species and mitogen-activated protein kinase expression in human renal proximal tubule epithelial cells. Korean J Physiol Pharmacol. 2018 Mar;22(2):135-143. 2. Moss ML, et al. Recent Advances in ADAM17 Research: A Promising Target for Cancer and Inflammation. Mediators Inflamm. 2017;2017:9673537. |
| 溶解性： |
soluble in DMSO |
| 保存条件： |
-20℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.002 ml |
10.008 ml |
20.016 ml |
| 5 mM |
0.4 ml |
2.002 ml |
4.003 ml |
| 10 mM |
0.2 ml |
1.001 ml |
2.002 ml |
| 50 mM |
0.04 ml |
0.2 ml |
0.4 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京