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• 产品描述： TAPI-1 is a TACE (ADAM17) inhibitor and blocks the shedding of several cell surface proteins. TAPI-1 is also a metalloproteinase (MMP) inhibitor

• 靶点： TACE (ADAM17), MMP;MMP

• 体外研究：
  TAPI-1 (1 µM for 30 min) increases cell viability in LPS-treated HK-2 cells. TAPI-1 attenuates oxidative stress and inflammatory cytokines LPS treatment significantly induces renal IL-6 and TNFα mRNA expression, while these changes is attenuated with TAPI-1 pretreatment in LPS-treated HK-2 cells. Cell Viability Assay Cell Line: LPS-treated HK-2 cells Concentration: 1 µM Incubation Time: 30 minutes (pre-treated) Result: Increased cell viability.

• 参考文献：
  1. Bae EH, et al. Tumor necrosis factor α-converting enzyme inhibitor attenuates lipopolysaccharide-induced reactive oxygen species and mitogen-activated protein kinase expression in human renal proximal tubule epithelial cells. Korean J Physiol Pharmacol. 2018 Mar;22(2):135-143. 2. Moss ML, et al. Recent Advances in ADAM17 Research: A Promising Target for Cancer and Inflammation. Mediators Inflamm. 2017;2017:9673537.

• 溶解性： soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.002 ml	10.008 ml	20.016 ml
  5 mM	0.4 ml	2.002 ml	4.003 ml
  10 mM	0.2 ml	1.001 ml	2.002 ml
  50 mM	0.04 ml	0.2 ml	0.4 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *