| 产品描述： | PI4KIIIbeta-IN-10 is a potent PI4KIIIβ inhibitor with an IC50 of 3.6 nM. |
| 靶点： |
PI4KIIIβ:3.6 nM (IC50);PI4KIIIα:3 μM (IC50);PI3Kδ:720 nM (IC50);PI3KC2γ:1 μM (IC50);PI3Kα:10 μM (IC50);PI3Kγ:20 μM (IC50);PI3K; PI4K |
| 体外研究： |
PI4KIIIbeta-IN-10 (Compound 10) is a potent PI4KIIIβ inhibitor with very minor off-target inhibition of PI4KIIIβ related lipid kinases. PI4KIIIbeta-IN-10 shows weak inhibition of PI3KC2γ (IC50 ~1 µM), PI3Kα (~10 µM), and PI4KIIIα (~3 µM), and <20% inhibition at concentrations up to 20 µM for PI4K2α, PI4K2β, and PI3Kβ. |
| 参考文献： |
1. Rutaganira FU, et al. Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ. J Med Chem. 2016 Mar 10;59(5):1830-9. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-20℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.103 ml |
10.513 ml |
21.027 ml |
| 5 mM |
0.421 ml |
2.103 ml |
4.205 ml |
| 10 mM |
0.21 ml |
1.051 ml |
2.103 ml |
| 50 mM |
0.042 ml |
0.21 ml |
0.421 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京