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KN-93 (phosphate) 99%

KN-93 (phosphate)

源叶(MedMol)
S84164
1913269-12-1
C26H32ClN2O8PS
599.0327
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S84164-1mg 99% ¥500.00元 预计交期:2-3天 - - -
源叶(MedMol) S84164-5mg 99% ¥1000.00元 预计交期:2-3天 - - -
源叶(MedMol) S84164-10mg 99% ¥1250.00元 预计交期:2-3天 - - -
源叶(MedMol) S84164-50mg 99% ¥5100.00元 预计交期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

KN-93 phosphate is a novel membrane-permeant synthetic inhibitor of purified neuronal CaMK-II, with Ki of 370 nM.
产品描述: KN-93 phosphate is a novel membrane-permeant synthetic inhibitor of purified neuronal CaMK-II, with Ki of 370 nM.
靶点: Ki: 370 nM (CaMK-II);CaMK
体外研究:
After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN-93 release, a peak of cells had progressed into S and G2-M. KN-93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts. KN-93 inhibits the H+, K+-ATPase activity but strongly dissipates the proton gradient formed in the gastric membrane vesicles and reduces the volume of luminal space. KN-93 (0.5 μM) prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations. Ca2+-independent CaM kinase activity is increased during early afterdepolarizations and this increase is prevented by KN-93
参考文献:
1. Tombes RM, et al. G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase). Cell Growth Differ. 1995 Sep;6(9):1063-70. 2. Li J, et al. Curcumin Attenuates Retinal Vascular Leakage by Inhibiting Calcium/Calmodulin-Dependent Protein Kinase II Activity in Streptozotocin-Induced Diabetes. Cell Physiol Biochem. 2016;39(3):1196-208. 3. Mamiya N, et al. Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitorKN-93. Biochem Biophys Res Commun. 1993 Sep 15;195(2):608-15. 4. Anderson ME, et al. KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J Pharmacol Exp Ther. 1998 Dec;287(3):996-1006.
溶解性: Soluble  in  DMSO、H2O
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 1.669 ml 8.347 ml 16.694 ml
5 mM 0.334 ml 1.669 ml 3.339 ml
10 mM 0.167 ml 0.835 ml 1.669 ml
50 mM 0.033 ml 0.167 ml 0.334 ml
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参考文献

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