Tacrine HCl hydrate 99%

Tacrine HCl hydrate

MedMol
S84342
206658-92-6
C13H17ClN2O
252.73988
9-氨基-1,2,3,4-四氢吖啶 盐酸盐 水合物
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
MedMol S84342-100mg 99% ¥285.00元 >10 - - -
MedMol S84342-500mg 99% ¥670.00元 5 - - -
MedMol S84342-2.5g 99% ¥3060.00元 预计交期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Tacrine hydrochloride (hydrate) is an inhibitor of both acetyl (AChE) and butyryl-cholinestrase (BChE) with IC50s of 31 nM and 25.6 nM, respectively.
产品描述: Tacrine hydrochloride (hydrate) is an inhibitor of both acetyl (AChE) and butyryl-cholinestrase (BChE) with IC50s of 31 nM and 25.6 nM, respectively.
靶点: IC50: 31 nM (AChE), 25.6 nM (BChE);AChR; AChE
体内研究: Pretreatment with Tacrine hydrochloride (hydrate) also modifies absolute levels of cocaine self-administration during reacquisition. Body weight declines approximately one-half percent over four days of treatment with intravenous Tacrine hydrochloride (hydrate). Delivery of Tacrine hydrochloride (hydrate) by osmotic pump does not alter either linear- or repeated- cocaine-induced locomotor activity. There is no significant main effect or interaction with Tacrine hydrochloride (hydrate) treatment on active lever responding during reinstatement. Post hoc comparisons indicate that rats self-administering cocaine has significantly lower alkaline phosphatase levels, relative to TTacrine hydrochloride (hydrate)- but not saline- treated rats evaluated by conditioned-place preference
参考文献: 1. Ahmed M, et al. Inhibition of two different cholinesterases by tacrine. Chem Biol Interact. 2006 Aug 25;162(2):165-71. 2. Grasing K, et al. Enduring effects of tacrine on cocaine-reinforced behavior: Analysis by conditioned-place preference, temporal separation from drug reward, and reinstatement. Pharmacol Res. 2015 Jul;97:40-7.
溶解性: H2O  :  100  mg/mL  (Need  ultrasonic)    DMSO  :  32  mg/mL  (Need  ultrasonic  and  warming)
保存条件: 2-8℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 3.957 ml 19.783 ml 39.566 ml
5 mM 0.791 ml 3.957 ml 7.913 ml
10 mM 0.396 ml 1.978 ml 3.957 ml
50 mM 0.079 ml 0.396 ml 0.791 ml
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参考文献

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摩尔浓度计算器

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