| 产品描述： | Frentizole, an FDA-approved immunosuppressant, is a Aβ-ABAD (binding alcohol dehydrogenase) interaction inhibitor with an IC50 value of 200 μM. Frentizole is used in studies of diseases related to rheumatoid arthritis and systemic lupus erythematosus |
| 靶点： |
Amyloid-β;BetaAmyloid |
| 体内研究： |
Frentizole (8.2 or 79.9 mg/kg/day for young mice in animal feedings, 52 weeks) can extend the life span of NZB/NZW mice |
| 参考文献： |
1. Meisel AD, et al. Effect of frentizole on mitogen-induced blastogenesis in human lymphocytes. J Immunopharmacol. 1979;1(4):483-95. 2. Walker SE, et al. Prolonged lifespans in female NZB/NZW mice treated with the experimental immunoregulatory drug frentizole. Arthritis Rheum. 1982 Nov;25(11):1291-7. 3. Yuli Xie, et al. Identification of small-molecule inhibitors of the Abeta-ABAD interaction. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4657-60. |
| 溶解性： |
DMSO : 12.5 mg/mL (41.76 mM; Need ultrasonic) |
| 保存条件： |
-20℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
3.341 ml |
16.703 ml |
33.406 ml |
| 5 mM |
0.668 ml |
3.341 ml |
6.681 ml |
| 10 mM |
0.334 ml |
1.67 ml |
3.341 ml |
| 50 mM |
0.067 ml |
0.334 ml |
0.668 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京