| 品牌 | 货号 | 产品规格 | 价格(RMB) | 库存（上海） | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
| 源叶(MedMol) | S84762-2mg | 98% | ￥170.00元 | 9 | - | - | - |
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| 源叶(MedMol) | S84762-5mg | 98% | ￥272.00元 | 3 | - | - | - |
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| 源叶(MedMol) | S84762-10mg | 98% | ￥476.00元 | 4 | - | - | - |
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| 源叶(MedMol) | S84762-25mg | 98% | ￥920.00元 | 4 | - | - | - |
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| 源叶(MedMol) | S84762-50mg | 98% | ￥1600.00元 | 5 | - | - | - |
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| 源叶(MedMol) | S84762-100mg | 98% | ￥2850.00元 | 5 | - | - | - |
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| 产品描述： STAT5-IN-1 是一种有效的选择性 STAT5 抑制剂，其对于STAT5β亚型的IC50值为47 μM | ||||||||||||||||||||
| 靶点： STAT5β(Cell-free assay):47 μM;STAT | ||||||||||||||||||||
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体外研究： STAT5-IN-1, the STAT5 phosphorylation specific inhibitor, selectively blocks the STAT5 signaling and decreases the percentage of CD4+CD25+Foxp3+ Tregs after SEC2 stimulation on murine splenocytes |
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体内研究： STAT5-IN-1, a STAT5 inhibitor, significantly attenuates atherosclerosis in ApoE-/- mice induced by HFD via decreasing inflammation. |
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| 细胞实验： Cell lines: murine splenocytes Concentrations: 0.47 mM Incubation Time: 3 days Method: Fresh murine splenocytes seeded in 24-well flat-bottom plates are treated with each inhibitor at final concentrations of 10 μM LY294002, 10 mM Trigonelline, 0.47 mM STAT5-IN-1, 50 μM SB431542, and 1 μM SIS3, or treated with 10 μg/mL anti-IL-2 neutralizing antibody, respectively, then cells are stimulated with 104 ng/mL SEC2 for 3 days in a humidified incubator at 37 ℃ with 5% CO2. | ||||||||||||||||||||
| 动物实验： Animal Models: ApoE-/- mice Dosages: 10 mg/kg Administration: p.o. | ||||||||||||||||||||
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参考文献： 1. Müller J, et al. Discovery of chromone-based inhibitors of the transcription factor STAT5. Chembiochem. 2008 Mar 25;9(5):723-7. 2. Li Y, et al. Induction of CD4+ regulatory T cells by stimulation with Staphylococcal Enterotoxin C2 through different signaling pathways. Biomed Pharmacother. 2021 Nov;143:112204. 3. Wang X, et al. STAT5 inhibitor attenuates atherosclerosis via inhibition of inflammation: the role of STAT5 in atherosclerosis. Am J Transl Res. 2021;13(3):1422-1431. |
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| 溶解性： Soluble in DMSO | ||||||||||||||||||||
| 保存条件： -20℃ | ||||||||||||||||||||
配置溶液浓度参考：
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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