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• 产品描述： STAT5-IN-1 是一种有效的选择性 STAT5 抑制剂，其对于STAT5β亚型的IC50值为47 μM

• 靶点： STAT5β(Cell-free assay):47 μM;STAT

• 体外研究：
  STAT5-IN-1, the STAT5 phosphorylation specific inhibitor, selectively blocks the STAT5 signaling and decreases the percentage of CD4+CD25+Foxp3+ Tregs after SEC2 stimulation on murine splenocytes

• 体内研究：
  STAT5-IN-1, a STAT5 inhibitor, significantly attenuates atherosclerosis in ApoE-/- mice induced by HFD via decreasing inflammation.

• 细胞实验： Cell lines: murine splenocytes Concentrations: 0.47 mM Incubation Time: 3 days Method: Fresh murine splenocytes seeded in 24-well flat-bottom plates are treated with each inhibitor at final concentrations of 10 μM LY294002, 10 mM Trigonelline, 0.47 mM STAT5-IN-1, 50 μM SB431542, and 1 μM SIS3, or treated with 10 μg/mL anti-IL-2 neutralizing antibody, respectively, then cells are stimulated with 104 ng/mL SEC2 for 3 days in a humidified incubator at 37 ℃ with 5% CO2.

• 动物实验： Animal Models: ApoE-/- mice Dosages: 10 mg/kg Administration: p.o.

• 参考文献：
  1. Müller J, et al. Discovery of chromone-based inhibitors of the transcription factor STAT5. Chembiochem. 2008 Mar 25;9(5):723-7. 2. Li Y, et al. Induction of CD4+ regulatory T cells by stimulation with Staphylococcal Enterotoxin C2 through different signaling pathways. Biomed Pharmacother. 2021 Nov;143:112204. 3. Wang X, et al. STAT5 inhibitor attenuates atherosclerosis via inhibition of inflammation: the role of STAT5 in atherosclerosis. Am J Transl Res. 2021;13(3):1422-1431.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.41 ml	17.049 ml	34.097 ml
  5 mM	0.682 ml	3.41 ml	6.819 ml
  10 mM	0.341 ml	1.705 ml	3.41 ml
  50 mM	0.068 ml	0.341 ml	0.682 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *