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Azeliragon (TTP488) 99%

1-PropanaMine, 3-[4-[2-butyl-1-[4-(4-chlorophenoxy)phenyl]-1H-iMidazol-4-yl]phenoxy]-N,N-diethyl-

源叶(MedMol)
S85925
603148-36-3
C32H38ClN3O2
532.124
氯丁胶乳;AZELIRAGON;阿齐瑞格;1-PropanaMine, 3-[4-[2-butyl-1-[4-(4-chlorophenoxy)phenyl]-1H-iMidazol-4-yl]phenoxy]-N,N-diethyl-;CRL 40G;3-(4-(2-butyl-1-(4-(4-chlorophenoxy)phenyl)-1H-imidazol-4-yl)phenoxy)-N,N
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S85925-1mg 99% ¥70.00元 7 - - -
源叶(MedMol) S85925-2mg 99% ¥120.00元 6 - - -
源叶(MedMol) S85925-5mg 99% ¥170.00元 8 - - -
源叶(MedMol) S85925-10mg 99% ¥260.00元 7 - - -
源叶(MedMol) S85925-25mg 99% ¥510.00元 5 - - -
源叶(MedMol) S85925-50mg 99% ¥880.00元 预计交期:2-3天 - - -
源叶(MedMol) S85925-100mg 99% ¥1490.00元 预计交期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Azeliragon (TTP488) is an orally bioavailable inhibitor of the receptor for advanced glycation end products (RAGE) in development as a potential treatment to slow disease progression in patients with mild Alzheimer’s disease (AD). Azeliragon also can cross the blood-brain barrier (BBB)
产品描述: Azeliragon (TTP488) is an orally bioavailable inhibitor of the receptor for advanced glycation end products (RAGE) in development as a potential treatment to slow disease progression in patients with mild Alzheimer’s disease (AD). Azeliragon also can cross the blood-brain barrier (BBB)
靶点: Amyloid-β;BetaAmyloid;advancedglycationendproducts
体内研究: Azeliragon (100 mcg/d; intraperitoneal injection; every day) treatment reduces syngeneic islet graft and islet allograft in NOD and B6 mice (Islets were isolated from young prediabetic NOD/LtJ mice and transplanted into NOD mice with spontaneous diabetes; islets were isolated from WT BALB/c mice and transplanted into B6 mice with diabetes)
参考文献: 1. Burstein AH, et al. Assessment of Azeliragon QTc Liability Through Integrated, Model-Based Concentration QTc Analysis. Clin Pharmacol Drug Dev. 2019 May;8(4):426-435. 2. Bongarzone S, et al. Targeting the Receptor for Advanced Glycation Endproducts (RAGE): A Medicinal Chemistry Perspective. J Med Chem. 2017 Sep 14;60(17):7213-7232. 3. Chen Y, et al. RAGE ligation affects T cell activation and controls T cell differentiation. J Immunol. 2008 Sep 15;181(6):4272-8.
溶解性: Soluble  in  DMSO
保存条件: RT
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 1.879 ml 9.396 ml 18.793 ml
5 mM 0.376 ml 1.879 ml 3.759 ml
10 mM 0.188 ml 0.94 ml 1.879 ml
50 mM 0.038 ml 0.188 ml 0.376 ml
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参考文献

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