| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S86185-2mg |
99.6% | ￥220.00 | 5 | - | - | - |
|
S86185-5mg |
99.6% | ￥320.00 | 9 | - | - | - |
|
S86185-10mg |
99.6% | ￥480.00 | 6 | - | - | - |
|
S86185-25mg |
99.6% | ￥720.00 | 6 | - | - | - |
|
S86185-50mg |
≥98% | ￥1230.00 | 货期：2-3天 | - | - | - |
|
iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT), with IC50 of 40.3 nM against Wnt responsive STF16 luciferase.
| 产品描述： | iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT), with IC50 of 40.3 nM against Wnt responsive STF16 luciferase. | ||||||||||||||||||||
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| 靶点： | IC50: 40.3 nM (Wnt responsive STF16 luciferase);Wnt/beta-catenin | ||||||||||||||||||||
| 体内研究： | iCRT14 (50 mg/kg, i.p.) markedly decreases CycD1, proliferation of the tumors in HCT116 xenografts | ||||||||||||||||||||
| 参考文献： | 1. Gonsalves FC, et al. An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. Proc Natl Acad Sci USA. 2011 Apr 12;108(15):5954-63. 2. Bilir B, et al. Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells. J Transl Med. 2013 Nov 4;11:280. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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