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S86590

Cabergoline

源叶(MedMol) 99%
  • 英文名:
  • Cabergoline
  • 别名:
  • 卡麦角林
  • CAS号:
  • 81409-90-7
  • 分子式:
  • C26H37N5O2
  • 分子量:
  • 451.6
  • 核磁/质谱:
品牌货号产品规格价格(RMB) 库存(上海) 北京 武汉 南京 数量计量单位 加入购物车...
源叶(MedMol) S86590-5mg 99% ¥425.00元 3 - - - EA 加入购物车
源叶(MedMol) S86590-10mg 99% ¥637.50元 8 - - - EA 加入购物车
源叶(MedMol) S86590-50mg 99% ¥2550.00元 7 - - - EA 加入购物车
源叶(MedMol) S86590-100mg 99% ¥4300.00元 5 - - - EA 加入购物车
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  • 提示:详情请下载说明书。
  • 产品描述: Cabergoline is an ergot derived-dopamine D2-like receptor agonist that has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively).
  • 靶点: D3 Receptor;D2 Receptor;DopamineReceptor;5-HTReceptor;Autophagy
  • 体内研究:
    Cabergoline has a longer elimination half-life (63 to 109 h) compared with other D2-like receptor agonists, both a long-lasting clinical effect following single-dose administration, and an improvement in the quality of life of patients with chronic diseases are expected. The most significant reduction in rapid eye movement (REM) sleep bout number occurred during the light phase, in which Cabergoline-injected female handled mice has 67.3% less REM sleep bouts (F(1,11)=12.892, P=0.004) than Cabergoline-injected females that are restrained, although the greatest number in reduction of REM sleep bouts occurr during the dark phase (82.3% fewer REM sleep bouts; F(1,11)=3.667, P=0.082). In male mice, Cabergoline reduces baseline Prolactin (PRL) levels (98.5%; F(1,6)=13.192, P=0.011) from 5.8±1.3 to 0.08 ng/mL within 2 hours of injection. After a 7-day recovery period, PRL levels return to values that are not different from baseline (5.0±0.60 ng/mL; F(1,6)=0.715, P=0.43).
  • 参考文献:
    1. Odaka H, et al. Cabergoline, dopamine D2 receptor agonist, prevents neuronal cell death under oxidative stress via reducing excitotoxicity. PLoS One. 2014 Jun 10;9(6):e99271. 2. Jefferson F, et al. A dopamine receptor d2-type agonist attenuates the ability of stress to alter sleep in mice. Endocrinology. 2014 Nov;155(11):4411-21.
  • 溶解性: Soluble  in  DMSO
  • 保存条件: 2-8℃
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 2.214 ml 11.072 ml 22.143 ml
    5 mM 0.443 ml 2.214 ml 4.429 ml
    10 mM 0.221 ml 1.107 ml 2.214 ml
    50 mM 0.044 ml 0.221 ml 0.443 ml
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