产品描述: CFMTI inhibits L-glutamate-induced intracellular Ca2+ mobilization in CHO cells expressing human and rat mGluR1a, with IC50s of 2.6 and 2.3 nM, respectively |
靶点:
Human mGluR1a:2.6 nM (IC50);Rat mGluR1a:2.3 nM (IC50);GluR |
参考文献:
1. Satow A et al. Unique antipsychotic activities of the selective metabotropic glutamate receptor 1 allosteric antagonist 2-cyclopropyl-5-[1-(2-fluoro-3-pyridinyl)-5-methyl-1H-1,2,3-triazol-4-yl]-2,3-dihydro-1H-isoindol-1-one. J Pharmacol Exp Ther. 2009 Jul;330(1):179-90. |
溶解性:
soluble in DMSO |
保存条件:
-20℃ |
配置溶液浓度参考:
|
1mg |
5mg |
10mg |
1 mM |
2.862 ml |
14.312 ml |
28.624 ml |
5 mM |
0.572 ml |
2.862 ml |
5.725 ml |
10 mM |
0.286 ml |
1.431 ml |
2.862 ml |
50 mM |
0.057 ml |
0.286 ml |
0.572 ml |
|
注意: |
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