Dabigatran Etexilate Mesylate 98%

Dabigatran Etexilate Mesylate

源叶(MedMol)
S86956
872728-81-9
C35H45N7O8S
723.84
达比加群酯甲磺酸
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S86956-5mg 98% ¥265.00元 >10 - - -
源叶(MedMol) S86956-10mg 98% ¥375.00元 >10 - - -
源叶(MedMol) S86956-25mg 98% ¥650.00元 >10 - - -
源叶(MedMol) S86956-50mg 98% ¥940.00元 >10 - - -
源叶(MedMol) S86956-100mg 98% ¥1330.00元 >10 - - -
源叶(MedMol) S86956-200mg 98% ¥1990.00元 >10 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Dabigatran etexilate mesylate is the orally active prodrug of dabigatran. Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI, Ki: 4.5 nM).
产品描述: Dabigatran etexilate mesylate is the orally active prodrug of dabigatran. Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI, Ki: 4.5 nM).
靶点: Thrombin
体内研究: Dabigatran prolonged the aPTT dose-dependently after intravenous administration in rats (0.3, 1 and 3 mg/kg) and rhesus monkeys (0.15, 0.3 and 0.6 mg/kg). Dose- and time-dependent anticoagulant effects were observed with dabigatran etexilate administered orally to conscious rats (10, 20 and 50 mg/kg) or rhesus monkeys (1, 2.5 or 5 mg/kg), with maximum effects observed between 30 and 120 min after administration, respectively. Patients treated with dabigatran etexilate experienced fewer ischaemic strokes (3.74 dabigatran etexilate vs 3.97 warfarin) and fewer combined intracranial hemorrhages and hemorrhagic strokes (0.43 dabigatran etexilate vs 0.99 warfarin) per 100 patient-years
参考文献: 1.Kansal AR, Sorensen SV, Gani R, Cost-effectiveness of dabigatran etexilate for the prevention of stroke and systemic embolism in UK patients withatrial fibrillation. Heart. 2012 Apr;98(7):573-8. 2.Wienen W, Stassen JM, Priepke H, In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally activeprodrug, dabigatran etexilate. Thromb Haemost. 2007 Jul;98(1):155-62.
溶解性: Soluble  in  DMSO
保存条件: 2-8℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 1.382 ml 6.908 ml 13.815 ml
5 mM 0.276 ml 1.382 ml 2.763 ml
10 mM 0.138 ml 0.691 ml 1.382 ml
50 mM 0.028 ml 0.138 ml 0.276 ml
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参考文献

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摩尔浓度计算器

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