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• 产品描述： (R)-(+)-Bay-K-8644 is a calcium channel inhibitor. (R)-(+)-Bay-K-8644 inhibits Ba2+ currents (IBa) (IC50=975 nM).

• 靶点： IC50: 975 nM (IBa);CalciumChannel; PPAR

• 体外研究：
  (R)-(+)-Bay-K-8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca2+ channel agonist. Each optical isomer possesses opposite effects on IBa, (R)-(+)-Bay-K-8644 as an antagonist and S(-)-Bay K 8644 as an agonist. (R)-(+)-Bay-K-8644 inhibits Ba2+ currents (IBa) (IC50=975 nM). When (R)-(+)-Bay-K-8644 (0.5 μM) is applied, IBa is suppressed to 71±10% of control. In the presence of (R)-(+)-Bay-K-8644IBa[1]. (R)-(+)-Bay-K-8644 is a calcium channel inhibitor

• 参考文献：
  1. Zhu HL, et al. Antagonistic actions of S(-)-Bay K 8644 on cyclic nucleotide-induced inhibition of voltage-dependent Ba(2+) currents in guinea pig gastric antrum. Naunyn Schmiedebergs Arch Pharmacol. 2008 Dec;378(6):609-15. 2. Sidaway P, et al. L-type Ca2+ channel sparklets revealed by TIRF microscopy in mouse urinary bladder smooth muscle. PLoS One. 2014 Apr 3;9(4):e93803.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.807 ml	14.033 ml	28.067 ml
  5 mM	0.561 ml	2.807 ml	5.613 ml
  10 mM	0.281 ml	1.403 ml	2.807 ml
  50 mM	0.056 ml	0.281 ml	0.561 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *