T-26c 98%

T-26c

MedMol
S87862
869296-13-9
C24H21N3O6S
479.51
CPD1612
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
MedMol S87862-5mg 98% ¥612.00元 4 - - -
MedMol S87862-10mg 98% ¥1020.00元 7 - - -
MedMol S87862-25mg 98% ¥2040.00元 6 - - -
源叶(MedMol) S87862-100mg 98% ¥6120.00元 预计交期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes
产品描述: T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes
靶点: IC50: 6.75 pM (MMP-13);MMP
体外研究: T-26c significantly inhibits the breakdown of collagen (87.4% inhibition at 0.1 μM) in IL-1β and oncostatin M stimulated cartilage.
体内研究: T-26c is well absorbed in all species at the oral dose of 10–20 mg/kg. Oral administration of the disodium salt formulations of T-26c to guinea pigs results in significant increases in AUC (8357 ng h/mL) and Cmax (1445 ng/ mL) compared with those of the free acid T-26c (AUC = 6478 ng h/ mL and Cmax= 911 ng/mL).
参考文献: 1. Nara H, et al. Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1″ binding site. Bioorg Med Chem. 2014 Oct 1;22(19):5487-505.
溶解性: Soluble  in  DMSO
保存条件: -20°C
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.085 ml 10.427 ml 20.855 ml
5 mM 0.417 ml 2.085 ml 4.171 ml
10 mM 0.209 ml 1.043 ml 2.085 ml
50 mM 0.042 ml 0.209 ml 0.417 ml
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参考文献

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摩尔浓度计算器

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