• 产品描述： SRI-011381是一种新型的TGF-beta信号通路激动剂，用来治疗阿尔茨海默病

• 靶点： TGF-β;TGF-beta/Smad

• 体内研究：
  SRI-011381, a small-molecule agonist of TGFβ signaling, has no effect on outflow tract (OFT) expansion in zebrafish, suggesting that hyperactivation of TGFβ signaling is not sufficient to induce aneurysm

• 细胞实验： Cell lines: pulmonary fibroblasts of silicosis mouse model Concentrations: 10 µM Incubation Time: -- Method: The tissues are extracted in a sterile environment, rinsed in PBS 3 times, and then cut into 1-mm3 tissue blocks. After repeated digestion with 0.25% trypsin at 37 ℃, the histolysate is evenly spread in a 10-cm petri dish. A high-glucose medium containing 10% fetal bovine serum, penicillin, and streptomycin is added to the petri dish. The cells are cultured in an incubator, and the medium is exchanged every 2-3 days. When the cells reached 80-90% confluence, they are passaged according to the ratio of 1: 3, and the fifth passage cells are taken for experimental study. Pulmonary fibroblasts are identified using anti-vimentin antibody with fluorescent secondary antibodies under a fluorescence microscope. For in vitro experiments, a range of concentrations of SF solution (0.04, 0.1, 0.18 and 0.28 mg/mL) are prepared for the treatment of fibroblasts. A 10 μM SRI-011381 solution is used for the activati

• 动物实验： Animal Models: Zebrafish carrying ltbp3fb28 and ltbp1fb29 Dosages: 500 µM Administration: exposed

• 参考文献：
  1. Hu L,et al.Exp Eye Res. 2019;182:44-56. 2. Han, Jingyin et al. Medical science monitor : international medical journal of experimental and clinical research vol. 27 e927978. 15 Jun. 2021, 3. Abrial M, et al. Dis Model Mech. 2022 Mar 1;15(3):dmm046979.

• 溶解性： Soluble  in  DMSO、Ethanol

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.035 ml	15.175 ml	30.351 ml
  5 mM	0.607 ml	3.035 ml	6.07 ml
  10 mM	0.304 ml	1.518 ml	3.035 ml
  50 mM	0.061 ml	0.304 ml	0.607 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

输入产品批号：

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *