| 品牌 | 货号 | 产品规格 | 价格(RMB) | 库存（上海） | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
| 源叶(MedMol) | S89158-5mg | 98% | ￥578.00元 | 5 | - | - | - |
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| 源叶(MedMol) | S89158-10mg | 98% | ￥740.00元 | 7 | - | - | - |
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| 源叶(MedMol) | S89158-25mg | 98% | ￥1156.00元 | 6 | - | - | - |
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| 源叶(MedMol) | S89158-100mg | 98% | ￥3400.00元 | 预计交期：2-3天 | - | - | - |
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| 产品描述： AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell. | ||||||||||||||||||||
| 靶点： ATM:6.2 nM (IC50);ATM:0.31 μM (IC50, in cell);ATM/ATR | ||||||||||||||||||||
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体外研究： AZ32 is a next-generation blood-brain barrier (BBB)-penetrating ATM inhibitor. AZ32 blocks the DNA damage response and radiosensitized GBM cells in vitro. |
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体内研究： AZ32, with enhanced BBB penetration, is highly efficient in vivo as radiosensitizer in syngeneic and human, orthotopic mouse glioma model compared with AZ31. AZ32 is a specific inhibitor of the ATM kinase that possesses good BBB penetration in mouse. Following a single oral dose of AZ32 (200 mg/kg) in mice, the free-brain concentrations of AZ32 are in excess of the cellular IC50 for approximately 22 hours. |
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参考文献： 1. Karlin J, et al. Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice. Mol Cancer Ther. 2018 Aug;17(8):1637-1647. |
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| 溶解性： Soluble in DMSO | ||||||||||||||||||||
| 保存条件： -20℃ | ||||||||||||||||||||
配置溶液浓度参考：
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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