| 产品描述： | ZINC05007751 is a potent NIMA-related kinase NEK6 inhibitor with an IC50 of 3.4 μM. ZINC05007751 shows antiproliferative activity against a panel of human cancer cell lines, and displays a synergistic effect with Cisplatin and Paclitaxel in a BRCA2 mutated ovarian cancer cell line. ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity was observed against NEK2, NEK7, and NEK9 |
| 靶点： |
MAPK |
| 体外研究： |
ZINC05007751 (6 μM-190 μM; 24 hours) inhibits the growth of MDA-MB-231, PEO1, NCI-H1299 and HCT-15 with IC50 below 100 µM. ZINC05007751 induces perturbation of PEO1 cell cycle. ZINC05007751 (ovarian cancer cells PEO1) shows synergism with Cisplatin, resulting in a significant reduction of Cisplatin IC50 from 7.9 to 0.1 µM, with combination ZINC05007751 (44 µM) + Cisplatin (10 µM) exhibiting the greatest synergistic effect. Cell Cytotoxicity Assay Cell Line: MDA-MB-231, PEO1, NCI-H1299 and HCT-15 cells Concentration: 6 μM-190 μM Incubation Time: 24 hours Result: Inhibited the growth of MDA-MB-231, PEO1, NCI-H1299 and HCT-15. |
| 参考文献： |
1. De Donato M, et al. Identification and antitumor activity of a novel inhibitor of the NIMA-related kinase NEK6. Sci Rep. 2018;8(1):16047. Published 2018 Oct 30. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-20℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
3.286 ml |
16.431 ml |
32.862 ml |
| 5 mM |
0.657 ml |
3.286 ml |
6.572 ml |
| 10 mM |
0.329 ml |
1.643 ml |
3.286 ml |
| 50 mM |
0.066 ml |
0.329 ml |
0.657 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京