| 品牌 | 货号 | 产品规格 | 价格(RMB) | 库存（上海） | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
| 源叶(MedMol) | S89704-5mg | 98% | ￥1275.00元 | 5 | - | - | - |
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| 源叶(MedMol) | S89704-10mg | 98% | ￥2040.00元 | 5 | - | - | - |
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| 源叶(MedMol) | S89704-25mg | 98% | ￥3825.00元 | 6 | - | - | - |
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| 源叶(MedMol) | S89704-100mg | 98% | ￥11475.00元 | 预计交期：2-3天 | - | - | - |
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| 产品描述： GW 590735 is a potent and selective PPARα agonist. GW 590735 showsEC50=4 nM on PPARα and at least 500-fold selectivity versus PPARδ and PPARγ. GW 590735 can be used for the research of dyslipidemia | ||||||||||||||||||||
| 靶点： PPAR | ||||||||||||||||||||
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体内研究： GW 590735 (0.5-5 mg/kg; orally twice a day for 5 days) is able to lower LDLc and triglycerides (TG) and increase HDL cholesterol in the Apo-A-I-transgenic mouse model (male C57BL/6 mice transgenic for human ApoA-I). GW 590735 (intravenous administration; 2.7 mg/kg; rat) treatment shows Cl, Vd, T1/2, and F% are 5 mL/min/kg, 1 L/kg, 2.4 hours and 47%, respectively. GW 590735 (intravenous administration; 2 mg/kg; dog) treatment shows Cl, Vd, T1/2, and F% are 13 mL/min/kg, 2.8 L/kg, 2.6 hours and 85%, respectively. |
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参考文献： 1. Sierra ML, et al. Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. J Med Chem. 2007;50(4):685-695. |
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| 溶解性： Soluble in DMSO | ||||||||||||||||||||
| 保存条件： -20°C | ||||||||||||||||||||
配置溶液浓度参考：
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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