产品描述: | UPGL00004 是一种有效的谷氨酰胺酶 C (GAC) 抑制剂 (IC50=29 nM; Kd=27 nM)。UPGL00004 强烈抑制高度侵袭性三阴性乳腺癌细胞系的增殖。 |
靶点: |
IC50: 29 nM (Glutaminase C); Kd: 27 nM (Glutaminase C);Glutaminase |
体外研究: |
UPGL00004 inhibits MDA-MB-231, HS578T and TSE cells with IC50s of 70, 129, and 262 nM, respectively. |
体内研究: |
The combination of UPGL00004 (1 mg/kg body weight) and Bevacizumab (2.5 mg/kg body weight) via intraperitoneal injection completely prevent any detectable increase in tumor size in a triple-negative breast cancer patient-derived tumor graft model. |
参考文献: |
1. Huang Q, et al. Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism. J Biol Chem. 2018 Mar 9;293(10):3535-3545. |
溶解性: |
soluble in DMSO |
保存条件: |
-20°C |
配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
1 mM |
1.87 ml |
9.352 ml |
18.703 ml |
5 mM |
0.374 ml |
1.87 ml |
3.741 ml |
10 mM |
0.187 ml |
0.935 ml |
1.87 ml |
50 mM |
0.037 ml |
0.187 ml |
0.374 ml |
|
注意: |
部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。 |