• 介绍：
   Methotrexate (Amethopterin) 是一种抗代谢 (antimetabolite) 和抗叶酸剂 (antifolate)，可抑制二氢叶酸还原酶，从而防止叶酸转化为四氢叶酸并抑制 DNA 合成。Methotrexate也是一种免疫抑制剂和抗肿瘤剂，用于类风湿关节炎和研究多种癌症 (如急性淋巴细胞白血病)。

• 熔点： 195°C

• 比旋光度： 21 ° (C=0·1, 1N NaOH)

• 外观： 黄色结晶性粉末

• 溶解性： DMSO  :  ≥  50  mg/mL  (110.03  mM)

• 敏感性： 对光和湿度敏感

• 储存条件： -20℃

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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• 31. [IF=7.9] Xian Lin et al."Sesamol serves as a p53 stabilizer to relieve rheumatoid arthritis progression and inhibits the growth of synovial organoids."PHYTOMEDICINE.10.1016/j.phymed.2023.155109

• 30. [IF=2.9] Jiao Wang et al."A Q-marker screening strategy based on ADME studies and systems biology for Chinese herbal medicine, taking Qianghuo Shengshi decoction in treating rheumatoid arthritis as an example."Molecular Omics.2023 Jul;:

• 29. [IF=8] Kaixuan Zhao et al."Gentiopicroside-Loaded Chitosan Nanoparticles Inhibit TNF-α-Induced Proliferation and Inflammatory Response in HaCaT Keratinocytes and Ameliorate Imiquimod-Induced Dermatitis Lesions in Mice."International Journal of Nanomedicine.

• 28. [IF=6.656] Fang-yuan Liu et al."Therapeutic effects of shikonin on adjuvant-induced arthritis in rats and cellular inflammation, migration and invasion of rheumatoid fibroblast-like synoviocytes via blocking the activation of Wnt/β-catenin pathway."PHYTOMEDICINE.202

• 27. [0] Xian Lin et al."Osthole regulates N6-methyladenosine-modified TGM2 to inhibit the progression of rheumatoid arthritis and associated interstitial lung disease."MedComm.2023 Feb;4(2):e219

• 26. [IF=6.986] Gan Peirong et al."A novel mechanism for inhibiting proliferation of rheumatoid arthritis fibroblast-like synoviocytes: geniposide suppresses HIF-1α accumulation in the hypoxic microenvironment of synovium."INFLAMMATION RESEARCH.2022 Sep;:1-14

• 25. [IF=5.307] Jian Chen et al."Novel isatin-based hybrids as potential anti-rheumatoid arthritis drug candidates: Synthesis and biological evaluation."BIOORGANIC CHEMISTRY.2022 Nov;128:106063

• 24. [IF=3.846] Shichao Wu et al."Methotrexate and 10-hydroxycamptothecine loaded pullulan nanoparticles with the targeting property for efficient cancer therapy."MATERIALS TECHNOLOGY

• 23. [IF=4.932] Bo Meng et al."AMSP-30 m as a novel HIF-1α inhibitor attenuates the development and severity of adjuvant-induced arthritis in rats: Impacts on synovial apoptosis, synovial angiogenesis and sonic hedgehog signaling pathway."Int Immunopharmacol. 2022 Feb;10

• 22. [IF=2.589] Shenghui Zhong et al."Hyaluronic Acid-Coated MTX-PEI Nanoparticles for Targeted Rheumatoid Arthritis Therapy."Crystals. 2021 Apr;11(4):321

• 21. [IF=3.361] Xiangyu Li et al."Folate receptor-targeting mesoporous silica-coated gold nanorod nanoparticles for the synergistic photothermal therapy and chemotherapy of rheumatoid arthritis."Rsc Adv. 2021 Jan;11(6):3567-3574

• 20. [IF=3.943] Yu-rong Mu et al."Acetazolamide ameliorates the severity of collagen-induced arthritis in rats: Involvement of inducing synovial apoptosis and inhibiting Wnt/β-catenin pathway."Int Immunopharmacol. 2021 Jan;90:107214

• 19. [IF=5.34] Li Cai et al."7-Hydroxycoumarin mitigates the severity of collagen-induced arthritis in rats by inhibiting proliferation and inducing apoptosis of fibroblast-like synoviocytes via suppression of Wnt/β-catenin signaling pathway."Phytomedicine. 2022 Jan;94:

• 18. [IF=5.455] He Lianhua et al."Shikonin attenuates rheumatoid arthritis by targeting SOCS1/JAK/STAT signaling pathway of fibroblast like synoviocytes."Chin Med-Uk. 2021 Dec;16(1):1-15

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• 15. [IF=2.69] Juan Wu et al."Facile synthesis of magnetic-/pH-responsive hydrogel beads based on Fe3O4 nanoparticles and chitosan hydrogel as MTX carriers for controlled drug release."J Biomat Sci-Polym E. 2016;27(15):1553-1568

• 14. [IF=3.329] Chengcheng Zou et al."Functional analysis of miR-181a and Fas involved in hepatitis B virus-related hepatocellular carcinoma pathogenesis."Exp Cell Res. 2015 Feb;331:352

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• 10. Li, Xiangyu, et al. "Folate receptor-targeting mesoporous silica-coated gold nanorod nanoparticles for the synergistic photothermal therapy and chemotherapy of rheumatoid arthritis." RSC Advances 11.6 (2021): 3567-3574.https://doi.org/10.1039/D0RA08689D

• 9. Mu, Y. R. , et al. "Acetazolamide ameliorates the severity of collagen-induced arthritis in rats: Involvement of inducing synovial apoptosis and inhibiting Wnt/β-catenin pathway." International Immunopharmacology 90(2021):107214.

• 8. Wang, Kejia, Chunhong Xie, and Daorong Chen. "Flap endonuclease 1 is a promising candidate biomarker in gastric cancer and is involved in cell proliferation and apoptosis." International journal of molecular medicine 33.5 (2014): 1268-1274. https://doi.org

• 7. 李炳彤. 艾拉莫德对类风湿关节炎患者外周血白细胞瓜氨酸化的影响及机制研究[D].吉林大学,2020.

• 6. 任泽宇,姜宏,许燕,石永芳.甲氨蝶呤PLGA微球制备工艺及体外释药性能考察[J].石河子大学学报(自然科学版),2020,38(06):767-772.

• 5. 段紫钰,李建国,陈静,刘鸿伟,李丽娜,周武,张守民.凉血消银颗粒剂对银屑病转基因小鼠模型miR-155/SOCS1轴的影响[J].天津医药,2020,48(11):1045-1049.

• 4. 刘春芳, 何莲花, 王靖霞,等. 风湿祛痛胶囊对类风湿关节炎滑膜Akt和MAPK信号通路的影响[J]. 中国实验方剂学杂志, 2019, 25(13):43-48.

• 3. 王靖霞, 刘春芳, 何莲花, et al. 风湿祛痛胶囊对大鼠胶原诱导性关节炎的影响[J]. 中国实验方剂学杂志, 2019, 25(02):89-95.

• 2. 刘春芳, 王靖霞, 何莲花,等. 风湿祛痛胶囊对Ⅱ型胶原诱导性关节炎大鼠滑膜血管新生的影响[J]. 中国中药杂志, 2019, 044(007):1457-1463.

• 1. 王靖霞, 刘春芳, 李逸群,等. 雷公藤多苷片抑制实验性类风湿关节炎血管新生的作用研究. 中国中药杂志.

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *