• 介绍：

   Gefitinib (ZD1839) 是一种有效，选择性和口服活性的 EGFR 酪氨酸激酶抑制剂，IC50 为 33 nM。Gefitinib 选择性抑制 EGF 刺激的肿瘤细胞生长 (IC50 为 54 nM)，并阻断 EGF 刺激的肿瘤细胞中 EGFR 自磷酸化。Gefitinib 还可诱导细胞自噬 (autophagy) 和凋亡 (apoptosis)，可用于癌症相关的研究，如肺癌和乳腺癌。

• 熔点： 119-120℃

• 沸点： 586.8℃

• 外观： 白色至米黄色粉末

• 溶解性： DMSO  :  125  mg/mL  (279.70  mM;  Need  ultrasonic)

• 储存条件： -20℃

• 用途： An EGFR-tyrosine kinase inhibitor

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

• 14. [3.5] Xiaowen Wang et al."Targeted degradation of KRAS protein in non-small cell lung cancer: Therapeutic strategies using liposomal PROTACs with enhanced cellular uptake and pharmacokinetic profiles."DRUG DEVELOPMENT RESEARCH.2024 Aug;85(5):e22241

• 13. [IF=5.1] Hongyan Lin et al."Modified Podophyllotoxin Phenoxyacetamide Phenylacetate Derivatives: Tubulin/AKT1 Dual-Targeting and Potential Anticancer Agents for Human NSCLC."JOURNAL OF NATURAL PRODUCTS.2023;XXXX(XXX):XXX-XXX

• 12. [IF=5.988] Wen Jiang et al."Rapid Determination of 9 Tyrosine Kinase Inhibitors for the Treatment of Hepatocellular Carcinoma in Human Plasma by QuEChERS-UPLC-MS/MS."Frontiers in Pharmacology.2022; 13: 920436

• 11. [IF=5.34] Hai-Qiao Wang et al."Schisandrin B targets cannabinoid 2 receptor in Kupffer cell to ameliorate CCl4-induced liver fibrosis by suppressing NF-κB and p38 MAPK pathway."Phytomedicine. 2022 Apr;98:153960

• 10. [IF=4.207] Jianghua Ding et al."LPCAT1 promotes gefitinib resistance via upregulation of the EGFR/PI3K/AKT signaling pathway in lung adenocarcinoma."J Cancer. 2022; 13(6): 1837–1847

• 9. [IF=4.759] Zhihua Song et al."Synthesis and evaluation of fosfomycin group end-capped packing materials for hydrophilic interaction liquid chromatography."J Chromatogr A. 2021 Oct;1656:462529

• 8. [IF=11.413] Yanqiu Gu et al."Development of 3-mercaptopropyltrimethoxysilane (MPTS)-modified bone marrow mononuclear cell membrane chromatography for screening anti-osteoporosis components from Scutellariae Radix."Acta Pharm Sin B. 2020 Oct;10:1856

• 7. [IF=3.935] Yanqiu Gu et al."Comparative two-dimensional HepG2 and L02/ cell membrane chromatography/ C18/ time-of-flight mass spectrometry for screening selective anti-hepatoma components from Scutellariae Radix."J Pharmaceut Biomed. 2019 Feb;164:550

• 6. Gu, Yanqiu, et al. "Development of 3-mercaptopropyltrimethoxysilane (MPTS)-modified bone marrow mononuclear cell membrane chromatography for screening anti-osteoporosis components from Scutellariae Radix." Acta Pharmaceutica Sinica B 10.10 (2020): 1856-186

• 5. Lin, Qing, et al. "Design of gefitinib-loaded poly (l-lactic acid) microspheres via a supercritical anti-solvent process for dry powder inhalation." International journal of pharmaceutics 532.1 (2017): 573-580.https://doi.org/10.1016/j.ijpharm.2017.09.051

• 4. Yanqiu, et al. "Comparative two-dimensional HepG2 and L02/ cell membrane chromatography/ C18/ time-of-flight mass spectrometry for screening selective anti-hepatoma components from Scutellariae Radix. " Journal of pharmaceutical and biomedical analysis 164

• 3. 吕昕,朱渊红,周林水,王真,刘正中.白花蛇舌草乙醇提取物联合吉非替尼对TGF-β_1诱导的肺腺癌细胞H358上皮间质化的干预作用[J].中国现代应用药学,2016,33(02):154-158.

• 2. 陈芝, 俞建东, 唐超园,等. 榄香烯注射液对吉非替尼在PC-9/GR细胞内转运动力学影响[J]. 中成药, 2018, 40(002):284-290.

• 1. 吕昕 周林水 陈瑞琳 等. shRNA干扰TTF-1基因对肺腺癌细胞EGFR-TKI敏感性及细胞上皮间质化的影响[J]. 浙江医学 2019 v.41(22):28-32+108.

输入产品批号：

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *