• 介绍： Sorafenib是Raf-1, B-Raf和VEGFR-2的多重激酶抑制剂，IC50分别为6 nM, 22 nM和90 nM。还能抑制野生型和V599E突变型BRAF活性。

• 熔点： 202-204℃

• 沸点： 523.3℃ at 760 mmHg

• 外观： 白色至灰白色固体

• 溶解性： Soluble  in  DMSO  (~20  mg/ml),  Hot  Methanol,  DMF  (~20  mg/ml),  1:2  solution  of  DMSO:PBS(PH  7.2  )  (~0.3  mg/ml),  100%  ethanol,  and  et

• 储存条件： -20℃

• 用途： An inhibitor of tyrosine protein kinases that targets the Raf/Mek/Erk pathway

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

• 14. [IF=4.3] Huanyan Wu et al."Ginsenoside Rk1 induces autophagy-dependent apoptosis in hepatocellular carcinoma by AMPK/mTOR signaling pathway."FOOD AND CHEMICAL TOXICOLOGY".2024 Apr;186:114587

• 13. [IF=5.6] Pengfei Ren et al."Astaxanthin exerts an adjunctive anti-cancer effect through the modulation of gut microbiota and mucosal immunity."INTERNATIONAL IMMUNOPHARMACOLOGY.2024 Feb;128:111553

• 12. [IF=5.2] Pengfei Ren et al."Astaxanthin Augmented the Anti-Hepatocellular Carcinoma Efficacy of Sorafenib Through the Inhibition of the JAK2/STAT3 Signaling Pathway and Mitigation of Hypoxia within the Tumor Microenvironment."MOLECULAR NUTRITION & FOOD RESEARCH.202

• 11. [IF=6.1] Pengfei Ren et al."Astaxanthin slows down skeletal muscle atrophy in H22 tumor-bearing mice during sorafenib treatment by modulating the gut microbiota."Food & Function.2023 Dec;:

• 10. [IF=14] Tian-Jiao Zhou et al."Glutathione depletion and dihydroorotate dehydrogenase inhibition actuated ferroptosis-augment to surmount triple-negative breast cancer."BIOMATERIALS.2024 Mar;305:122447

• 9. [IF=6.1] Pengfei Ren et al."Dietary supplementation with astaxanthin enhances anti-tumor immune response and aids the enhancement of molecularly targeted therapy for hepatocellular carcinoma."Food & Function.2023 Aug;:

• 8. [IF=14] Tian-Jiao Zhou et al."Tumor microenvironment-initiated lipid redox cycling for efficient triple-negative breast cancer therapy."BIOMATERIALS.2023 Sep;300:122205

• 7. [IF=6.575] Pengfei Ren et al."Astaxanthin supplementation assists sorafenib in slowing skeletal muscle atrophy in H22 tumsor-bearing mice via reversing abnormal glucose metabolism."MOLECULAR NUTRITION & FOOD RESEARCH.2023 May;:2300076

• 6. [14.026] Linlin Qu et al."Ginsenoside Rk3 is a novel PI3K/AKT-targeting therapeutics agent that regulates autophagy and apoptosis in hepatocellular carcinoma."Journal of Pharmaceutical Analysis.2023 Mar;:

• 5. [IF=6.388] Bei Bei Zhou et al."Vegetable-derived indole enhances the melanoma-treating efficacy of chemotherapeutics."PHYTOTHERAPY RESEARCH.2022 Jul;:

• 4. [IF=5.988] Wen Jiang et al."Rapid Determination of 9 Tyrosine Kinase Inhibitors for the Treatment of Hepatocellular Carcinoma in Human Plasma by QuEChERS-UPLC-MS/MS."Frontiers in Pharmacology.2022; 13: 920436

• 3. [IF=10.435] Li Zhe et al.Sorafenib and triptolide loaded cancer cell-platelet hybrid membrane-camouflaged liquid crystalline lipid nanoparticles for the treatment of hepatocellular carcinoma.J Nanobiotechnol. 2021 Dec;19(1):1-12

• 2. 刘博佳,宁青,钟荣玲,夏智,姜子瑜,宋捷,韦英杰.羽扇豆醇对人肝癌细胞HepG2和SK-HEP-1侵袭、转移的影响及机制研究[J].中国中药杂志,2020,45(24):6028-6035.

• 1. 黄宇哲 桂双英 储晓琴.Box-Behnken响应面法优化索拉非尼PLGA-TPGS聚合物纳米粒的处方与工艺[J].安徽中医药大学学报 2019 38(01):80-86.

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *