- 产品描述: BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML) research
- 靶点: GSK3α:66 nM (IC50);GSK3α:4.8 μM (Kd);GSK-3β(WT):515 nM (IC50);GSK-3
- 体内研究:
BRD0705 (30 mg/kg; oral gavage; twice daily; NSG mice) treatment impairs leukemia initiation and prolongs survival in AML mouse models
- 参考文献:
1. Wagner FF, et al. Exploiting an Asp-Glu switch in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med. 2018 Mar 7;10(431). pii: eaam8460.
- 溶解性: Soluble in DMSO
- 保存条件: -20℃
- 配置溶液浓度参考:
1mg 5mg 10mg 1 mM 3.111 ml 15.556 ml 31.112 ml 5 mM 0.622 ml 3.111 ml 6.222 ml 10 mM 0.311 ml 1.556 ml 3.111 ml 50 mM 0.062 ml 0.311 ml 0.622 ml
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)