货号	规格	价格	上海	北京	珠海	武汉
S28059-1mg	99.80%	￥750.00 S28059-1mg ￥750.00 现货	2 4 2	2	2	-
S28059-5mg	99.80%	￥2500.00 S28059-5mg ￥2500.00 现货	2 1 2	1	-	-
S28059-10mg	99.80%	￥3490.00 S28059-10mg ￥3490.00 现货	2 2	-	-	-
S28059-25mg	99.80%	￥5780.00 S28059-25mg ￥5780.00 现货	16 >10	-	-	-
S28059-100mg	99.80%	￥9160.00 S28059-100mg ￥9160.00 现货	7 7	-	-	-

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产品描述：

Semaglutide, a long-acting GLP-1 analogue, is a glucagon-like peptide-1 (GLP-1) receptor agonist. Semaglutide has the potential for type 2 diabetes treatment.

靶点：

GLP-1 receptor;GlucagonReceptor

体外研究：

Semaglutide has two amino acid substitutions compared to human GLP-1 (Aib8, Arg34) and is derivatized at lysine 26. The GLP-1R affinity of Semaglutide is 0.38±0.06 nM. Semaglutide is a GLP-1 analogue with 94% sequence omology to human GLP-1.

体内研究：

The plasma half-life of Semaglutide is 46h in mini-pigs following i.v. administration and semaglutide has an MRT of 63.6h after s.c. dosing to mini-pigs. Semaglutide improves 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced motor impairments. In addition, Semaglutide rescues the decrease of tyrosine hydroxylase (TH) levels, alleviates the inflammation response, reduces lipid peroxidation, inhibits the apoptosis pathway, and also increases autophagy- related protein expression, to protect dopaminergic neurons in the substantia nigra and striatum. Moreover, the long-acting GLP-1 analogue semaglutide is superior to NN-2211 in most parameters.

参考文献：

1. Marso SP, et al. Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. N Engl J Med. 2016 Nov 10;375(19):1834-1844. 2. Zhang L, et al. Neuroprotective effects of the novel GLP-1 long acting analogue semaglutide in the MPTP Parkinson's disease mouse model. Neuropeptides. 2018 Oct;71:70-80. 3. Dhillon S, et al. Semaglutide: First Global Approval. Drugs. 2018 Feb;78(2):275-284.

溶解性：

Soluble in DMSO、H2O（用HCL 调节，pH≈1）

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	0 ml	0 ml	0 ml
5 mM	0 ml	0 ml	0 ml
10 mM	0 ml	0 ml	0 ml
50 mM	0 ml	0 ml	0 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(1篇)

1. [IF=4.8] Luyan Sun et al."Effects of semaglutide on metabolism and gut microbiota in high-fat diet-induced obese mice."Frontiers in Pharmacology.2025 Jun;16:

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Semaglutide

L-Histidyl-2-methylalanyl-L-alpha-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-alpha-glutamylglycyl-L-glutaminyl-L-alanyl-L

参考文献(1篇)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)