• 产品描述： Quisinostat dihydrochloride (JNJ-26481585 dihydrochloride) is an orally available, potent pan-HDAC inhibitor with IC50s of 0.11 nM, 0.33 nM, 0.64 nM, 0.46 nM, and 0.37 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11, respectively. Quisinostat dihydrochloride has a broad spectrum antitumoral activity

• 靶点： HDAC1:0.11 nM (IC50);HDAC2:0.33 nM (IC50);HDAC11:0.37 nM (IC50);HDAC10:0.46 nM (IC50);HDAC5:3.69 nM (IC50);HDAC8:4.26 nM (IC50);HDAC3:4.86 nM (IC50);HDAC9:32.1 nM (IC50);HDAC6:76.8 nM (IC50);HDAC7:119 nM (IC50);Apoptosis;HDAC;Autophagy

• 体内研究：
  JNJ-26481585 (40 mg/kg; p.o.; once daily, for 3 days) as a potent HDAC1 inhibitor p21waf1,cip1 ZsGreen tumors in vivo. JNJ-26481585 induces continuous H3 acetylation in tumor tissue in vivo. JNJ-26481585 (10 mg/kg; once daily; i.p.; for 14 days) strongly inhibits the growth of large pre-established HCT116 colon xenografts.

• 参考文献：
  1. Arts J, et al. JNJ-26481585, a novel second-generation oral histone deacetylase inhibitor, shows broad-spectrum preclinical antitumoral activity. Clin Cancer Res. 2009 Nov 15;15(22):6841-51.

• 溶解性： DMSO  :  31.25  mg/mL  (66.86  mM;  ultrasonic  and  warming  and  heat  to  70°C)

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.14 ml	10.698 ml	21.395 ml
  5 mM	0.428 ml	2.14 ml	4.279 ml
  10 mM	0.214 ml	1.07 ml	2.14 ml
  50 mM	0.043 ml	0.214 ml	0.428 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *