货号	规格	价格	上海	北京	珠海	武汉
S49560-10mg	99.30%	￥135.00 S49560-10mg ￥135.00 现货	2005 >10	-	-	-
S49560-50mg	99.30%	￥300.00 S49560-50mg ￥300.00 现货	403 2 >10	-	2	-
S49560-500mg	99.30%	￥1800.00 S49560-500mg ￥1800.00 现货	47 >10	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

Nintedanib (BIBF 1120)是一种有效的三重血管激酶抑制剂，对VEGFR1/2/3， FGFR1/2/3和PDGFRα/β均有抑制作用，其IC50分别为34 nM/13 nM/13 nM， 69 nM/37 nM/108 nM和59 nM/65 nM。

靶点：

VEGFR1 34 nM (IC50);VEGFR2 13 nM (IC50);VEGFR3 13 nM (IC50);FGFR1 69 nM (IC50);FGFR2 37 nM (IC50);FGFR3 108 nM (IC50)

体内研究：

Nintedanib (BIBF 1120)（每日口服 25-100 mg/kg）在所有肿瘤模型中均具有高活性，包括在裸鼠体内生长的人类肿瘤异种移植瘤和同源大鼠肿瘤模型。这在 3 天后的肿瘤灌注磁共振成像中很明显，5 天后血管密度和血管完整性降低，生长抑制显著。
Nintedanib 可口服，在体内肿瘤模型中表现出令人鼓舞的疗效，同时耐受性良好。

溶解性：

DMSO 6 mg/mL Water <1 mg/mL Ethanol 3 mg/mL

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.853 ml	9.266 ml	18.532 ml
5 mM	0.371 ml	1.853 ml	3.706 ml
10 mM	0.185 ml	0.927 ml	1.853 ml
50 mM	0.037 ml	0.185 ml	0.371 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(10篇)

10. [IF=4.6] Xiaoyu Gao, et al. "Nebulized delivery of multi-modular stem cell-derived exosomes for the treatment of pulmonary fibrosis"Nanomedicine-Nanotechnology Biology and Medicine, 2026 Jun;74:102925 9. [IF=3.7] Xue Yang et al."Anti-fibrotic activity of nobiletin and nintedanib: In vitro and in vivo evidence in pulmonary fibrosis models."CELLULAR SIGNALLING.2026 Jan;:112364 8. [IF=12.5] Binghua Wang et al."A softness zwitterionic micelles efficiently deliver inhaled nintedanib by enhancing airway mucus penetration."Science Advances.2026 Jan;12(1) 7. [IF=3.4] Liu Shuyin et al."Preparation, Characterization and Evaluation of Nintedanib Amorphous Solid Dispersions with Enhanced Oral Bioavailability."AAPS PHARMSCITECH.2024 Aug;25(6):1-13 6. [IF=7.9] Yang Ruan et al."The Dual Role of 20(S)-protopanaxadiol in Alleviating Pulmonary Fibrosis through the Gut-Lung Axis."PHYTOMEDICINE".2024 May;:155699

5. [IF=5.1] Hong Li et al."Qingkailing granule alleviates pulmonary fibrosis by inhibiting PI3K/AKT and SRC/STAT3 signaling pathways."BIOORGANIC CHEMISTRY".2024 Mar;:107286 4. [IF=4.927] Sijie Wei et al."Isolation, Characterization, and Anti-Idiopathic Pulmonary Fibrosis Activity of a Fucoidan from Costaria costata."MOLECULES.2023 Jan;28(11):4343 3. [IF=5.735] Guo-qing Ren et al."Ginseng saponin metabolite 20(S)-protopanaxadiol relieves pulmonary fibrosis by multiple-targets signaling pathways."Journal of Ginseng Research.2023 Jan;: 2. [IF=4.36] Zhenghua Wu et al."Schisandrol A, the main active ingredient of Schisandrae Chinensis Fructus, inhibits pulmonary fibrosis through suppression of the TGF-β signaling pathway as revealed by UPLC-Q-TOF/MS, network pharmacology and experimental verification. 1. [IF=7.79] Xin Chang et al."Nanoengineered immunosuppressive therapeutics modulating M1/M2 macrophages into the balanced status for enhanced idiopathic pulmonary fibrosis therapy."Nanoscale. 2020 Apr;12(16):8664-8678

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

尼达尼布

Nintedanib (BIBF 1120)

参考文献(10篇)

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)