S80142 |
NSC 23766 |
源叶(MedMol) | 99% |
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- 产品描述: NSC 23766 trihydrochloride is an inhibitor of Rac1 activation.
- 靶点: Ras;Apoptosis;Apoptosis;Rho;Ras
- 体内研究:
NSC23766 (2.5 mg/kg/day, i.p.) significantly attenuates the onset of spontaneous diabetes in NOD mice, without significant effects on the growth (body weights) of the mice. NSC23766 significantly increases the expression of Rac1 and CHOP, a marker for ER-stress, in islets from NOD mice
- 参考文献:
1. Veluthakal R, et al. NSC23766, a Known Inhibitor of Tiam1-Rac1 Signaling Module, Prevents the Onset of Type 1 Diabetes in the NOD Mouse Model. Cell Physiol Biochem. 2016;39(2):760-7. 2. Song SJ, et al. Inhibition of Rac1 GTPase activity affects porcine oocyte maturation and early embryo development. Sci Rep. 2016 Oct 3;6:34415 3. Zhao L, et al. Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1, GDF9 and BMP15 transcription in mice. Sci Rep. 2016 Apr 6;6:23972 4. Wang Y, et al. Involvement of Rac1 signalling pathway in the development and maintenance of acute inflammatory pain induced by bee venom injection. Br J Pharmacol. 2016 Mar;173(5):937-50
- 溶解性: DMSO : 33.33 mg/mL (62.77 mM; Need ultrasonic) H2O : ≥ 32 mg/mL (60.27 mM)
- 保存条件: -20℃
- 配置溶液浓度参考:
1mg 5mg 10mg 1 mM 1.883 ml 9.417 ml 18.834 ml 5 mM 0.377 ml 1.883 ml 3.767 ml 10 mM 0.188 ml 0.942 ml 1.883 ml 50 mM 0.038 ml 0.188 ml 0.377 ml
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)