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• 产品描述： Faropenem sodium是具有口服活性的β-内酰胺抗生素，用于研究治疗肺结核和社区获得性肺炎的试验中。

• 靶点： Antibacterial;Antibiotic

• 细胞实验： Cell lines: RAW macrophages Concentrations: 7, 28, or 56 μg/ml Incubation Time: -- Method: RAW macrophages were grown in Dulbecco modified Eagle medium containing l-glutamine and sodium pyruvate (PAA Laboratories) supplemented with 10% fetal bovine serum. About 2.5 × 104 cells were seeded into each well of a 48-well plate and were infected with green fluorescent protein (GFP)-expressing M. tuberculosis (MTB_NDT1) at a multiplicity of infection (MOI) of 10:1 for 4 h. After infection, the monolayers were washed three times with fresh medium to remove nonadherent bacteria and then exposed to fresh medium with or without isoniazid (0.75 μg/ml), faropenem (7, 28, or 56 μg/ml), or meropenem (5, 25, or 50 μg/ml) plus clavulanate (2.5 μg/ml). Medium (containing antibiotics) was changed every 24 h. At various time points, macrophages were washed once with 1× PBS and then lysed using 0.5% Triton X-100. The macrophage lysates were diluted in PBS containing 0.05% Tween 80, serial dilutions were plated on 7H10 agar, a

• 动物实验： Animal Models: Adult female C57BL/6J mice Dosages: 500 mg/kg Administration: oral

• 参考文献：
  1. Dhar N, et al. Antimicrob Agents Chemother. 2015, 59(2):1308-19.

• 溶解性： Soluble  in  DMSO、H2O

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.254 ml	16.271 ml	32.542 ml
  5 mM	0.651 ml	3.254 ml	6.508 ml
  10 mM	0.325 ml	1.627 ml	3.254 ml
  50 mM	0.065 ml	0.325 ml	0.651 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *