S80194 |
GSK2334470 |
源叶(MedMol) | 99% |
- 提示:详情请下载说明书。
- 产品描述: GSK2334470 is a highly specific and potent inhibitor of PDK1 with an IC50 of 10 nM.
- 靶点: IC50: 10 nM(PDK1);PDK
- 体内研究:
The efficacy of the PDK1 inhibitor (PDKi) GSK2334470 is tested in newborn BrafV600E::Pten−/−mice subjected to systemic administration of 4-HT. Twice weekly administration of PDK1 results in marked inhibition of pigmented lesions and concomitant melanomagenesis, as well as significant inhibition of lung metastases, seen by H&E staining-based quantification (~80%), and lymph node metastases as by S100 immunostaining, similar to the phenotype seen upon genetic ablation of Pdk1
- 参考文献:
1. Najafov A, et al. Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1. Biochem J.?2011 Jan 15;433(2):357-69. 2. Qi L, et al. PDK1-mTOR signaling pathway inhibitors reduce cell proliferation in MK2206 resistant neuroblastoma cells. Cancer Cell Int.?2015 Sep 29;15:91. 3. Scortegagna M, et al. Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf(V600E)::Pten(-/-) melanoma. Oncogene. 2014 Aug 21;33(34):4330-9.
- 溶解性: DMSO : ≥ 50 mg/mL (108.09 mM)
- 保存条件: -20℃
- 配置溶液浓度参考:
1mg 5mg 10mg 1 mM 2.162 ml 10.809 ml 21.617 ml 5 mM 0.432 ml 2.162 ml 4.323 ml 10 mM 0.216 ml 1.081 ml 2.162 ml 50 mM 0.043 ml 0.216 ml 0.432 ml
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)