S80208 |
XMD8-87 |
源叶(MedMol) | 98% |
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- 产品描述: XMD8-87 is a potent TNK2 inhibitor with IC50 values of 38 and 113 nM for the D163E and R806Q mutations, respectively
- 靶点: IC50: 38 nM (TNK2, D163E mutation), 113 nM (TNK2, R806Q mutation);Tyrosinase;PPAR
- 体外研究:
XMD8-87 potently inhibits the growth of the TNK2 mutant expressing cell lines while having little or no effect on the control cells out to the highest tested concentrations (1,000 nM). XMD8-87 has IC50s of 38 nM and 113 nM for the D163E and R806Q mutations. The effects of XMD8-87 on TNK2 cell lines are largely due to on-target effects on TNK2. Auto-phosphorylation of overexpressed TNK2 mutants could be blocked with TNK2 inhibitor XMD8-87
- 参考文献:
1. Maxson JE, et al. Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis.
- 溶解性: soluble in DMSO
- 保存条件: -20℃
- 配置溶液浓度参考:
1mg 5mg 10mg 1 mM 2.245 ml 11.223 ml 22.446 ml 5 mM 0.449 ml 2.245 ml 4.489 ml 10 mM 0.224 ml 1.122 ml 2.245 ml 50 mM 0.045 ml 0.224 ml 0.449 ml
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质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)