Dubermatinib

    
98%

TP-0903

源叶(MedMol)
S80285 一键复制产品信息
1341200-45-0
C24H30ClN7O2S
516.0587
TP0903
货号 规格 价格 上海 北京 武汉 南京 购买数量
S80285-5mg 98% ¥530.00 6 - - -
S80285-10mg 98% ¥850.00 6 - - -
S80285-25mg 98% ¥1700.00 6 - - -
S80285-100mg 98% ¥5100.00 货期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

TP-0903 is a potent and selective Axl kinase inhibitor.

产品描述: TP-0903 is a potent and selective Axl kinase inhibitor.
靶点: Apoptosis;TAM Receptor;Apoptosis;TAMReceptor
体外研究: In pancreatic cancer cells (PSN-1), TP-0903 shows strong antiproliferative activity with IC50 of 6 M. TP-0903 also induces strong G2/M arrest by potently inhibiting Aurora A and B. In CLL B cells from all the patients with CLL, TP-0903 causes a dose-dependent induction of massive apoptosis by targeting phosphorylated Axl, and overcomes CLL BMSC-mediated protection of CLL B cells from apoptosis.
体内研究: In the adult rat hippocampus, the intracerebroventricular administration of SAG (2.5 nM) significantly increases the number of newly generated cells and extends survival of hippocampal cells. [3] In mice, SAG (20 μg/g, i.p.) effectively prevents GC-induced neonatal cerebellar developmental abnormalities.
细胞实验: For cell proliferation assays, 45 μL containing 1000 cells per well are seeded into solid white 384-well plates in appropriate media. The following day, TP-0903 is diluted in serum free growth media to 10x desired concentrations and 5 μL is added to each well. Combined compound and cells are incubated for 96 hours. Following incubation, 40 μL of ATP-Lite solution is added to each well, incubated for an additional 10 minutes at room temperature and luminescence is measured on an microplate reader
参考文献: 1. Mollard A, Warner SL, Call LT, Wade ML, Bearss JJ, Verma A, Sharma S, Vankayalapati H, Bearss DJ. Design, Synthesis and Biological Evaluation of a Series of Novel Axl Kinase Inhibitors. ACS Med Chem Lett. 2011 Dec 8;2(12):907-912. 2. Sinha S, et al. Targeted Axl Inhibition Primes Chronic Lymphocytic Leukemia B Cells to Apoptosis and Shows Synergistic/Additive Effects in Combination with BTK Inhibitors. Clin Cancer Res. 2015, 21(9), 2115-2126.
溶解性: soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 1.938 ml 9.689 ml 19.378 ml
5 mM 0.388 ml 1.938 ml 3.876 ml
10 mM 0.194 ml 0.969 ml 1.938 ml
50 mM 0.039 ml 0.194 ml 0.388 ml
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参考文献

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