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• 产品描述： Kenpaullone is a potent inhibitor of CDK1/cyclin B and GSK-3β, with IC50s of 0.4 μM and 23 nM, and also inhibits CDK2/cyclin A, CDK2/cyclin E, and CDK5/p25 with IC50s of 0.68 μM, 7.5 μM, 0.85 μM, respectively. Kenpaullone, a small molecule inhibitor of KLF4, reduces self-renewal of breast cancer stem cells and cell motility in vitro.

• 靶点： Cdk1/cyclin B：0.4 μM (IC50)；cdk2/cyclin A：0.68 μM (IC50)；CDK5/p35：0.85 μM (IC50)；CDK2/cyclinE：7.5 μM (IC50)；GSK-3β：0.023 μM (IC50)；erk1：20 μM (IC50)；erk2：9 μM (IC50)；c-raf：38 μM (IC50);GSK-3;CDK

• 参考文献：
  1. Zaharevitz DW, et al. Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases. Cancer Res. 1999 Jun 1;59(11):2566-9. 2. Lyssiotis CA, et al. Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4. Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):8912-7. 3. F Yu, et al. Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion. Oncogene. 2011 May 5;30(18):2161-72.

• 溶解性： DMSO  :  ≥  35  mg/mL  (106.97  mM)

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.056 ml	15.282 ml	30.564 ml
  5 mM	0.611 ml	3.056 ml	6.113 ml
  10 mM	0.306 ml	1.528 ml	3.056 ml
  50 mM	0.061 ml	0.306 ml	0.611 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *