S80346 |
IWP L6 |
| 源叶(MedMol) | ≥98%(HPLC) |
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- 产品描述： IWP L6 (Porcn Inhibitor III) is a Porcn inhibitor with an EC50 of 0.5 nM.
- 靶点： EC50 Value: 0.5 nM
- 体外研究：
IWP-L6 (Porcn Inhibitor III) effectively suppressed the phosphorylation of dishevelled 2 (Dvl2) in HEK293 cells, a biochemical event associated with many Wnt-dependent cellular responses. IWP-L6 inhibits Wnt mediated branching morphogenesis in cultured embryonic kidneys .
- 体内研究：
IWP-L6 (Porcn Inhibitor III) is stable in human plasma over 24 h, it was rapidly metabolized in rat plasma (t1/2 = 190 min), murine plasma (t1/2 = 2 min), and the murine liver S9 fractions (t1/2 = 26 min). The major metabolites are the amide cleavage products. Similar species-dependent metabolitic profiles due to the involvement of carboxylesterase (CES) have been reported with other drug candidates. Despite its modest metabolic stability in mouse-derived plasma, IWP-L6 was highly active in zebrafish. IWP-L6 exhibited more potent activity
- 参考文献：
1. Wang, X., et al., The development of highly potent inhibitors for porcupine. J Med Chem, 2013. 56(6): p. 2700-4.
- 溶解性： Soluble in DMSO
- 保存条件： -20°C
- 配置溶液浓度参考：
1mg 5mg 10mg 1 mM 2.116 ml 10.58 ml 21.16 ml 5 mM 0.423 ml 2.116 ml 4.232 ml 10 mM 0.212 ml 1.058 ml 2.116 ml 50 mM 0.042 ml 0.212 ml 0.423 ml
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)
