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S80398

AG-1478 (Tyrphostin AG-1478)

源叶(MedMol) 99%
  • 英文名:
  • 4-(3-Chloroanilino)-6,7-Dimethoxyquinazoline Hydrochloride
  • 别名:
  • 次黄嘌呤.6-羟基嘌呤; 6-羟基嘌呤;;AG-1478 hydrochloride; Tyrphostin AG 1478; AG-1478;
  • CAS号:
  • 153436-53-4
  • 分子式:
  • C16H15Cl2N3O2
  • 分子量:
  • 352.2
  • 核磁/质谱:
品牌货号产品规格价格(RMB) 库存(上海) 北京 武汉 南京 数量计量单位 加入购物车...
源叶(MedMol) S80398-2mg 99% ¥216.00元 5 - - - EA 加入购物车
源叶(MedMol) S80398-5mg 99% ¥304.00元 6 - - - EA 加入购物车
源叶(MedMol) S80398-10mg 99% ¥432.00元 5 - - - EA 加入购物车
源叶(MedMol) S80398-25mg 99% ¥800.00元 6 - - - EA 加入购物车
源叶(MedMol) S80398-50mg 99% ¥1200.00元 6 - - - EA 加入购物车
源叶(MedMol) S80398-100mg 99% ¥2240.00元 2 - - - EA 加入购物车
源叶(MedMol) S80398-200mg 99% ¥3200.00元 预计交期:2-3天 - - - EA 加入购物车
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参考文献

质检证书(COA)

摩尔浓度计算器

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  • 提示:详情请下载说明书。
  • 产品描述: AG-1478 (Tyrphostin AG-1478) is a selective EGFR tyrosine kinase inhibitor with IC50 of 3 nM. AG-1478 has antiviral effects against HCV and encephalomyocarditis virus (EMCV).
  • 靶点: EGFR:3 nM (IC50);HCV;EMCV ;EGFR;HCVProtease;InfluenzaVirus;HER;PDGFR
  • 体内研究:
    Administration of AG-1478 (AG1478) significantly reduces myocardial inflammation, fibrosis, apoptosis, and dysfunction in both two obese mouse models. ApoE-/- mice are first fed with HFD for 8 weeks (ApoE-HFD), and then administrated with AG-1478 (10 mg/kg/day) or 542 (10 mg/kg/day) for another 8 weeks by oral gavage. AG-1478 or 542 treatment blocks HFD induced cardiac EGFR phosphorylation in vivo, without affecting the plasma level of low density lipoprotein (LDL) and total triglyceride (TG). Administration of EGF (10 nM) leads to a robust and reproducible elevation in EGFR phosphorylation that can be blocked by AG-1478 (AG1478), a known inhibitor of EGFR phosphorylation. Increasing doses of Polyfect (PF) result in a significant reduction in EGF-induced EGFR phosphorylation (p<0.05) but this is to a lesser extent than observed with AG1478
  • 参考文献:
    1. Bojko A, et al. The effect of tyrphostins AG494 and AG1478 on the autocrine growth regulation of A549 and DU145 cells. Folia Histochem Cytobiol. 2012 Jul 5;50(2):186-95. 2. Li W, et al. EGFR Inhibition Blocks Palmitic Acid-induced inflammation in cardiomyocytes and Prevents Hyperlipidemia-induced Cardiac Injury in Mice. Sci Rep. 2016 Apr 18;6:24580. 3. Akhtar S, et al. Cationic Polyamidoamine Dendrimers as Modulators of EGFR Signaling In Vitro and In Vivo. PLoS One. 2015 Jul 13;10(7):e0132215. 4. Dorobantu CM, et al. Tyrphostin AG1478 Inhibits Encephalomyocarditis Virus and Hepatitis C Virus by Targeting Phosphatidylinositol 4-Kinase IIIα. Antimicrob Agents Chemother. 2016 Sep 23;60(10):6402-6.
  • 溶解性: DMSO  :  50  mg/mL  (158.35  mM;  Need  ultrasonic)
  • 保存条件: 2-8℃
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 2.839 ml 14.196 ml 28.393 ml
    5 mM 0.568 ml 2.839 ml 5.679 ml
    10 mM 0.284 ml 1.42 ml 2.839 ml
    50 mM 0.057 ml 0.284 ml 0.568 ml
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质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)


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