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• 产品描述： Deracoxib (SC-046) is a COX-2 inhibitor with >48-fold selectivity over COX-1. It also exhibits inhibitory activity against phosphodiesterase (Ki = 3.6 μM against human PDE4D3).

• 靶点： COX2;PDE4(Cell-free assay):3.6 μM;Apoptosis;COX

• 细胞实验： Cell lines: MC4R-GLO cells Concentrations: 10 µM Incubation Time: 5 min Method: MC4R-GLO cells were plated in 12 well culture dishes in DMEM/F12 supplemented with 5% fetal bovine serum. Cells were incubated in serum-free medium over night before the experiment. Cells were then treated with the indicated concentration of α-MSH or vehicle for 5 min at 37°C in the presence or absence of 10 µM deracoxib or imperatorin. Dishes were then placed on ice and cells were scraped in 1x LDS-PAGE sample buffer with 100 mM DTT. Proteins were resolved by SDS-PAGE.

• 参考文献：
  1. Millis DL, et al. Vet Ther. 2002, 3(4):453-64. 2. Pantel J, et al. Eur J Pharmacol. 2011, 660(1):139-47.

• 溶解性： Soluble  in  DMSO、Ethanol

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.517 ml	12.583 ml	25.165 ml
  5 mM	0.503 ml	2.517 ml	5.033 ml
  10 mM	0.252 ml	1.258 ml	2.517 ml
  50 mM	0.05 ml	0.252 ml	0.503 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *