S80505 |
LY310762 |
源叶(MedMol) | ≥95% |
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- 产品描述: LY310762 is a selective 5-HT1D receptor antagonist (Ki=249 nM) with a weak affinity for 5-HT1B receptor. LY310762 effectively abolishes the renal vasodilatory effects of 5-HTSumatriptan (HY-B0121B)-induced decrease in excitatory postsynaptic potential (EPSC) amplitude
- 靶点: 5-HT1D Receptor:249 nM (Ki);5-HTReceptor
- 体内研究:
LY310762 (10 mg/kg; i.p.; single) significantly increases the extracellular 5-HT concentration produced by Fluoxetine (selective serotonin re-uptake inhibitor) in vivo. LY310762 (1 mg/kg; i.v.; single) abolishes 5-HT vasodilator effects in phenylephrine-infusion rats model
- 参考文献:
1. Pullar IA, et al. The role of the 5-HT1D receptor as a presynaptic autoreceptor in the guinea pig. Eur J Pharmacol. 2004 Jun 16;493(1-3):85-93. 2. García-Pedraza JÁ, et al. Pharmacological evidence that 5-HT1D activation induces renal vasodilation by NO pathway in rats. Clin Exp Pharmacol Physiol. 2015 Jun;42(6):640-7. 3. Choi IS, Cho JH, An CH, Jung JK, Hur YK, Choi JK, Jang IS. 5-HT(1B) receptors inhibit glutamate release from primary afferent terminals in rat medullary dorsal horn neurons. Br J Pharmacol. 2012 Sep;167(2):356-67.
- 溶解性: Soluble in DMSO
- 保存条件: -20℃
- 配置溶液浓度参考:
1mg 5mg 10mg 1 mM 2.321 ml 11.603 ml 23.205 ml 5 mM 0.464 ml 2.321 ml 4.641 ml 10 mM 0.232 ml 1.16 ml 2.321 ml 50 mM 0.046 ml 0.232 ml 0.464 ml
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质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)