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• 产品描述： Dantrolene depresses excitation-contraction coupling in skeletal muscle by binding to the ryanodine receptor 1 and decreasing intracellular calcium concentration. Ryanodine receptors mediate the release of calcium from the sarcoplasmic reticulum, an essential step in muscle contraction. Dantrolene Sodium is the sodium salt form of dantrolene, a hydantoin derivative, and direct-acting skeletal muscle relaxant.

• 靶点： Autophagy;Calcium Channel

• 体内研究：
  In contrast of the slow soleus (SOL) muscle, Dantrolene sodium (5 mg/kg) has a greater inhibitory on the twitch contraction of the fast extensor digitorum longus (EDL) muscle.

• 参考文献：
  1. Büyükokuroğlu ME., et al. In vitro antioxidant properties of dantrolene sodium. Pharmacol Res. 2001 Dec;44(6):491-4. 2. Leslie GC., et al. The action of dantrolene sodium on rat fast and slow muscle in vivo. Br J Pharmacol. 1981 Apr;72(4):665-72.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.504 ml	12.522 ml	25.044 ml
  5 mM	0.501 ml	2.504 ml	5.009 ml
  10 mM	0.25 ml	1.252 ml	2.504 ml
  50 mM	0.05 ml	0.25 ml	0.501 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *