S80566 |
Anamorelin |
MedMol | 99% |
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- 产品描述: Anamorelin (RC-1291) is a potent ghrelin receptor agonist with EC50 value of 0.74 nM in the FLIPR assay.
- 靶点: Ki: 0.7 nM (ghrelin receptor) EC50: 0.74 nM (ghrelin receptor);GHSR
- 体内研究:
In rats, Anamorelin (ANAM) at an oral dose of 3, 10, or 30 mg/kg once daily significantly increases both food intake and body weight from Day 2 to Day 7 of treatment compared with the vehicle control. The cumulative change in food intake and weight gain increases dose-dependently, and these changes are significant at all dose levels (P<0.05) compared to the control. Administration of Anamorelin at a single oral dose of 3, 10, or 30 mg/kg induces a dose-dependent increase in plasma GH levels and GH AUC0-6h in rats
- 参考文献:
1. Pietra C, et al. Anamorelin HCl (ONO-7643), a novel ghrelin receptor agonist, for the treatment of cancer anorexia-cachexiasyndrome: preclinical profile. J Cachexia Sarcopenia Muscle. 2014 Dec;5(4):329-37.
- 溶解性: DMSO : ≥ 100 mg/mL (182.92 mM)
- 保存条件: -20℃
- 配置溶液浓度参考:
1mg 5mg 10mg 1 mM 1.829 ml 9.146 ml 18.292 ml 5 mM 0.366 ml 1.829 ml 3.658 ml 10 mM 0.183 ml 0.915 ml 1.829 ml 50 mM 0.037 ml 0.183 ml 0.366 ml
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输入产品批号:
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)