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• 产品描述： ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective for Aurora A/B than MEK1, Src, Lck and has little effect against CDK1/2/4, Plk1, Chk1, etc.

• 靶点： Apoptosis;Aurora Kinase;MEK;Src;Apoptosis;MEK;Src;AuroraKinase

• 细胞实验： Cell number is evaluated by crystal violet staining. In brief, cells in 96-well plates are fixed with 1% glutaraldehyde. Then cells are stained with 0.1% crystal violet. The unbound dye is removed by washing with water. Bound crystal violet is solubilized with 0.2% Triton X-100. Light extinction which increases linearly with the cell number is analyzed at 570 nm using an ELISA reader.(Only for Reference)

• 参考文献：
  1. Ditchfield C, et al. J Cell Biol. 2003, 161(2), 267-280. 2. Zhang L, et al. J Obstet Gynaecol Res. 2011, 37(6), 591-600. 3. Teperek-Tkacz M, et al. Cell Cycle. 2010, 9(23), 4674-4687. 4. Georgieva I, et al. Neuroendocrinology. 2010, 91(2), 121-130.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	1.947 ml	9.735 ml	19.471 ml
  5 mM	0.389 ml	1.947 ml	3.894 ml
  10 mM	0.195 ml	0.974 ml	1.947 ml
  50 mM	0.039 ml	0.195 ml	0.389 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *