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• 产品描述： Cyclic somatostatin (SRIF-14) is a growth hormone-release inhibiting factor used in the treatment of severe, acute hemorrhages of gastroduodenal ulcers. Cyclic somatostatin is a neuropeptide co-stored with acetylcholine in the cardiac parasympathetic innervation, exerts influences directly on contraction of ventricular cardiomyocytes. Cyclic somatostatin inhibits the contractile response of isoprenaline with an IC50 value of 13 nM. Cyclic somatostatin can be used for the research of cardiovascular disease

• 靶点： IC50: 13 nM (contractile response of isoprenaline)

• 体内研究：
  Cyclic somatostatin (5 μg/kg; i.v. per hour once for 18-22 hours) affects visceral metabolism in ruminants

• 参考文献：
  1. Murray F, et al. Positive and negative contractile effects of somatostatin-14 on rat ventricular cardiomyocytes. J Cardiovasc Pharmacol. 2001 Mar;37(3):324-32. 2. Bell D, et al. SRIF receptor subtype expression and involvement in positive and negative contractile effects of somatostatin-14 (SRIF-14) in ventricular cardiomyocytes. Cell Physiol Biochem. 2008;22(5-6):653-64. 3. https://pubmed.ncbi.nlm.nih.gov/9374319/

• 溶解性： H2O  :  100  mg/mL  (61.05  mM;  Need  ultrasonic)    DMF  :  100  mg/mL  (61.05  mM;  Need  ultrasonic)

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	0.611 ml	3.053 ml	6.105 ml
  5 mM	0.122 ml	0.611 ml	1.221 ml
  10 mM	0.061 ml	0.305 ml	0.611 ml
  50 mM	0.012 ml	0.061 ml	0.122 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *