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• 产品描述： Suprofen is an IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic.

• 靶点： COX;PGE Synthase;COX;PGESynthase

• 体内研究：
  Suprofen combined with PGF2 alpha blocks induction of uterine contractions, suggesting the possibility that Suprofen also antagonizes PGF2 alpha receptor binding. Suprofen are effective at preventing BAB disruption after paracentesis in dogs, indicating their potential usefulness for treatment of prostaglandin-mediated ocular disease. Suprofen (3.7 mg/kg, i.v.) induces a marked decrease in the firing evoked in arthritic rats by ankle mobilization.

• 参考文献：
  1. Cirli OO, et al. J Control Release, 2004, 96(1), 85-96. 2. Fujita H, et al. Photodermatol Photoimmunol Photomed, 11992-11993, 9(5), 203-208. 3. O'Donnell JP, et al. Drug Metab Dispos, 2003, 31(11), 1369-1377. 4. Hahn DW, et al. Prostaglandins, 1982, 23(1), 1-16. 5. Starrs SM, et al. Photochem Photobiol, 2000, 72(3), 291-297.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.842 ml	19.208 ml	38.416 ml
  5 mM	0.768 ml	3.842 ml	7.683 ml
  10 mM	0.384 ml	1.921 ml	3.842 ml
  50 mM	0.077 ml	0.384 ml	0.768 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *