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S80717

PS-1145

源叶(MedMol) 99%
  • 英文名:
  • N-(6-CHLORO-9H-PYRIDO[3,4-B]INDOL-8-YL)-3-PYRIDINECARBOXAMIDE DIHYDROCHLORIDE
  • 别名:
  • PS-1145 DIHYDROCHLORIDE;IKK Inhibitor X;PS 1145;N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)pyridine-3-carboxamide
  • CAS号:
  • 431898-65-6
  • 分子式:
  • C17H13Cl3N4O
  • 分子量:
  • 395.67032
  • 核磁/质谱:
品牌货号产品规格价格(RMB) 库存(上海) 北京 武汉 南京 数量计量单位 加入购物车...
源叶(MedMol) S80717-2mg 99% ¥140.00元 10 - - - EA 加入购物车
源叶(MedMol) S80717-5mg 99% ¥212.00元 10 - - - EA 加入购物车
源叶(MedMol) S80717-10mg 99% ¥355.00元 8 - - - EA 加入购物车
源叶(MedMol) S80717-25mg 99% ¥710.00元 6 - - - EA 加入购物车
源叶(MedMol) S80717-50mg 99% ¥1210.00元 4 - - - EA 加入购物车
源叶(MedMol) S80717-100mg 99% ¥2050.00元 预计交期:2-3天 - - - EA 加入购物车
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参考文献

质检证书(COA)

摩尔浓度计算器

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  • 提示:详情请下载说明书。
  • 产品描述: PS-1145 is an IκB kinase (IKK) inhibitor with an IC50 of 88 nM.
  • 靶点: IKK:88 nM (IC50);Apoptosis;IκB/IKK
  • 体内研究:
    Administration of either Bortezomib or PS-1145 (50 mg/kg) results in a significant decrease in serum levels of all 3 cytokines that is nonsignificantly different from those in mice that underwent transplantation with TCD BM alone. PS1145 is injected intracerebroventricular (icv) as a pretreatment to block hypothalamic inflammation induced by IL-4 in adult male Wistar rats consuming a high-fat diet (HFD) over an 11-day period. The four groups of rats according to icv pretreatment/treatment condition are Veh/Veh, Veh/IL-4, PS1145/Veh, and PS1145/IL-4. Rats in the Veh/IL-4 group display increased weight gain on the HFD compared with the Veh/Veh group (P<0.05 on days 6-9). Importantly, the effect of icv IL-4 administration to increase body fat mass during high-fat (HF) feeding is completely blocked by icv PS1145 pretreatment at a dose that has no independent effect on body composition (on day 8: P<0.001, PS1145/Veh vs. PS1145/IL-4; P=not significant, PS1145/Veh vs. Veh/Veh). In PS1145/IL-4 injected rats, IL-1β mRNA content is decreased by ~75% compared with that of Veh/IL-4-injected rats
  • 参考文献:
    1. Hideshima T, et al. NF-kappa B as a therapeutic target in multiple myeloma. J Biol Chem. 2002 May 10;277(19):16639-47. 2. Vodanovic-Jankovic S, et al. NF-kappaB as a target for the prevention of graft-versus-host disease: comparative efficacy of bortezomib and PS-1145. Blood. 2006 Jan 15;107(2):827-34. 3. Oh-I S, et al. Central administration of interleukin-4 exacerbates hypothalamic inflammation and weight gain during high-fat feeding. Am J Physiol Endocrinol Metab. 2010 Jul;299(1):E47-53.
  • 溶解性: DMSO  :  20.83  mg/mL  (64.54  mM;  Need  ultrasonic)
  • 保存条件: 2-8℃
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 2.527 ml 12.637 ml 25.274 ml
    5 mM 0.505 ml 2.527 ml 5.055 ml
    10 mM 0.253 ml 1.264 ml 2.527 ml
    50 mM 0.051 ml 0.253 ml 0.505 ml
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