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• 产品描述： QNZ (EVP4593) shows strong inhibitory effects on NF-κB transcriptional activation and TNF-α production with IC50s of 11 and 7 nM, respectively. QNZ (EVP4593) is a neuroprotective inhibitor of SOC channel.

• 靶点： NF-κB:11 nM (IC50, in human Jurkat cells transfected with pNFκB-Luc);TNF;NF-κB

• 参考文献：
  1. Tobe M, et al. Discovery of quinazolines as a novel structural class of potent inhibitors of NF-kappa B activation. 2. Nekrasov ED, et al. Manifestation of Huntington's disease pathology in human induced pluripotent stem cell-derived neurons. Mol Neurodegener. 2016 Apr 14;11:27. 3. Wu J, et al. Enhanced Store-Operated Calcium Entry Leads to Striatal Synaptic Loss in a Huntington's Disease Mouse Model. J Neurosci. 2016 Jan 6;36(1):125-41.

• 溶解性： DMSO  :  ≥  37  mg/mL  (103.81  mM)

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.806 ml	14.028 ml	28.057 ml
  5 mM	0.561 ml	2.806 ml	5.611 ml
  10 mM	0.281 ml	1.403 ml	2.806 ml
  50 mM	0.056 ml	0.281 ml	0.561 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

• 2. [IF=6.986] Tang Guanxiu et al."Inhibition of ANXA2 regulated by SRF attenuates the development of severe acute pancreatitis by inhibiting the NF-κB signaling pathway."INFLAMMATION RESEARCH.2022 Jul;:1-12

• 1. Zhang, Zhi Hong, et al. "Chelidonine inhibits TNF‐α‐induced inflammation by suppressing the NF‐κB pathways in HCT116 cells." Phytotherapy Research 32.1 (2018): 65-75.https://doi.org/10.1002/ptr.5948

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *