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S80797

Coelenterazine

源叶(MedMol) 98%
  • 英文名:
  • 别名:
  • 腔肠素
  • CAS号:
  • 55779-48-1
  • 分子式:
  • C26H21N3O3
  • 分子量:
  • 423.463
  • MDL:
  • MFCD00467176
  • 核磁/质谱:
品牌货号产品规格价格(RMB) 库存(上海) 北京 武汉 南京 数量计量单位 加入购物车...
源叶(MedMol) S80797-1mg 98% ¥680.00元 9 - - - EA 加入购物车
源叶(MedMol) S80797-5mg 98% ¥2125.00元 3 - - - EA 加入购物车
源叶(MedMol) S80797-10mg 98% ¥3400.00元 4 - - - EA 加入购物车
源叶(MedMol) S80797-25mg 98% ¥5950.00元 2 - - - EA 加入购物车
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参考文献

质检证书(COA)

摩尔浓度计算器

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  • 提示:详情请下载说明书。
  • 产品描述: Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. Renilla luciferase and substrate coelenterazine has been used as the bioluminescence donor in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions. Coelenterazine is a superoxide anion-sensitive chemiluminescent probe and it can also be used in chemiluminescent detection of peroxynitrite
  • 靶点: Reactive Oxygen Species
  • 体外研究:
    HCT-8 control cells, transiently expressing Renilla luciferase (RLuc), showed low bioluminescence due to P-glycoprotein–mediated efflux transport of coelenterazine. By comparison, transiently expressing RLuc HCT-8 cells, wherein P-glycoprotein was down-regulated with shRNAi, showed high bioluminescence。
  • 体内研究:
    The in vivo growth potential of HCC1806-RR was monitored by injecting animals with coelenterazine (2 mg/kg) i.v. and exposing them to a charged-coupled device (CCD) camera 5 minutes later. Rluc activity was detected as light emitted from the tumor cells and acquired as a pseudo-color image superimposed over a black and white photograph of the animal. All mice demonstrated very high Rluc activity at the primary site with the majority of mice simultaneously showing metastases to inguinal ILNs。
  • 参考文献:
    1. Markova SV, et al, Coelenterazine-dependent luciferases. Biochemistry (Mosc). 2015 Jun;80(6):714-32. 2. Lucas M, et al. Coelenterazine is a superoxide anion-sensitive chemiluminescent probe: its usefulness in the assay of respiratory burst in neutrophils. Anal Biochem. 1992 Nov 1;206(2):273-7. 3. Pichler A, et al. In vivo RNA interference-mediated ablation of MDR1 P-glycoprotein. Clin Cancer Res. 2005 Jun 15;11(12):4487-94. 4. Volk-Draper LD, et al. Novel model for basaloid triple-negative breast cancer: behavior in vivo and response to therapy. Neoplasia. 2012 Oct;14(10):926-42.
  • 溶解性: Soluble  in  Ethanol
  • 保存条件: -20℃
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 2.361 ml 11.807 ml 23.615 ml
    5 mM 0.472 ml 2.361 ml 4.723 ml
    10 mM 0.236 ml 1.181 ml 2.361 ml
    50 mM 0.047 ml 0.236 ml 0.472 ml
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